{"id":"aranidipine","rwe":[],"tags":[{"label":"aranidipine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Voltage-gated L-type calcium channel","category":"target"},{"label":"CACNA1C","category":"gene"},{"label":"CACNA1D","category":"gene"},{"label":"Active","category":"status"},{"label":"Hypertensive disorder","category":"indication"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"sapresta","offLabel":[],"synonyms":["aranidipine","sapresta"],"timeline":[],"brandName":"Sapresta","ecosystem":[{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"target":"Voltage-gated L-type calcium channel","targets":[{"gene":"CACNA1C","source":"DrugCentral","target":"Voltage-gated L-type calcium channel","protein":"Voltage-dependent L-type calcium channel subunit alpha-1C"},{"gene":"CACNA1D","source":"DrugCentral","target":"Voltage-gated L-type calcium channel","protein":"Voltage-dependent L-type calcium channel subunit alpha-1D"}],"modality":"Small Molecule","drugClass":"aranidipine","explanation":"Think of it like a gate that controls the flow of calcium into the heart and blood vessels. When this gate is open, calcium rushes in and makes the heart beat faster and the blood vessels constrict. Aranidipine blocks this gate, slowing down the heart rate and widening the blood vessels, which helps to lower blood pressure.","oneSentence":"Aranidipine works by blocking the L-type calcium channel, which reduces the amount of calcium entering the heart and blood vessels, leading to lower blood pressure.","technicalDetail":"Aranidipine acts as a selective blocker of the L-type calcium channel, specifically targeting the α1C subunit, which is responsible for the inward flow of calcium ions during cardiac and vascular smooth muscle contraction."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/234","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ARANIDIPINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:44:47.883560","biosimilars":[],"competitors":[{"drugName":"nicardipine","drugSlug":"nicardipine","fdaApproval":"1988-12-21","patentExpiry":"Dec 26, 2027","patentStatus":"Patent protected","relationship":"same-target"}],"genericName":"aranidipine","indications":{"approved":[{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nicardipine","brandName":"nicardipine","genericName":"nicardipine","approvalYear":"1988","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"4Y7UR6X2PO","CHEBI":"CHEBI:31232","INN_ID":"7071","UMLSCUI":"C0165312","ChEMBL_ID":"CHEMBL2104030","KEGG_DRUG":"D01562","DRUGBANK_ID":"DB09229","PUBCHEM_CID":"2225","IUPHAR_LIGAND_ID":"11744","MESH_SUPPLEMENTAL_RECORD_UI":"C059427"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sapresta is a small molecule modality. It is also known by other names, including ARANIDIPINE, ARANIDIPINO, MPC-1304, MPC1304.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}