{"id":"aprotonin-epsilon-aminocaproic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Thrombosis"},{"rate":null,"effect":"Myocardial infarction"},{"rate":null,"effect":"Stroke"},{"rate":null,"effect":"Renal dysfunction"},{"rate":null,"effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aprotinin is a serine protease inhibitor that directly inhibits plasmin and kallikrein, while epsilon aminocaproic acid is a lysine analog that competitively inhibits plasminogen activation. Together, they work synergistically to prevent excessive fibrin degradation and reduce perioperative blood loss in surgical patients.","oneSentence":"This combination inhibits fibrinolysis by blocking plasmin-mediated clot breakdown, thereby reducing bleeding during and after surgery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:50.704Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of perioperative blood loss in cardiac surgery"},{"name":"Reduction of transfusion requirements in major surgical procedures"}]},"trialDetails":[{"nctId":"NCT00156520","phase":"PHASE4","title":"Platelet Function And Aggregometry In Patients With Aortic Valve Stenosis","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2005-03","conditions":"Hemorrhage","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"aprotonin; epsilon aminocaproic acid","genericName":"aprotonin; epsilon aminocaproic acid","companyName":"University of Rochester","companyId":"university-of-rochester","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination inhibits fibrinolysis by blocking plasmin-mediated clot breakdown, thereby reducing bleeding during and after surgery. Used for Reduction of perioperative blood loss in cardiac surgery, Reduction of transfusion requirements in major surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}