{"id":"aprotinin-or-tranexamic-acid","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Hypertension"}]},"_chembl":{"chemblId":"CHEMBL877","moleculeType":"Small molecule","molecularWeight":"157.21"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Tranexamic acid is a synthetic derivative of the amino acid lysine. It binds to plasminogen and prevents its activation to plasmin, which is the primary enzyme responsible for fibrinolysis. By inhibiting fibrinolysis, tranexamic acid reduces the breakdown of blood clots and prevents excessive bleeding.","oneSentence":"Tranexamic acid works by inhibiting the activation of plasminogen to plasmin, thereby reducing fibrinolysis and preventing excessive bleeding.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:52.643Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical bleeding"},{"name":"Menorrhagia"}]},"trialDetails":[{"nctId":"NCT00396760","phase":"PHASE3","title":"Comparison of Aprotinin and Tranexamic Acid in Routine Cardiac Surgery","status":"UNKNOWN","sponsor":"German Heart Center","startDate":"2005-01","conditions":"Bleeding and Cardiac Surgery, Allogeneic Blood Transfusion, Aortic Valve Replacement","enrollment":220}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16479,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"aprotinin or tranexamic acid","genericName":"aprotinin or tranexamic acid","companyName":"German Heart Center","companyId":"german-heart-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tranexamic acid works by inhibiting the activation of plasminogen to plasmin, thereby reducing fibrinolysis and preventing excessive bleeding. Used for Surgical bleeding, Menorrhagia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}