{"id":"apronal","rwe":[],"tags":[{"label":"apronal","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05CM12","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:43:40.924172","allNames":"isodormid","offLabel":[],"synonyms":["apronalide","allylisopropylacetylurea","apronal","isodormid"],"timeline":[],"brandName":"Isodormid","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"apronal","explanation":"Think of apronal like a key that unlocks a specific process in the body. When it binds to its target, it can either turn the process up or down, depending on what's needed. However, since we don't know what apronal's target is, we can't say exactly how it works or what it does.","oneSentence":"Apronal is believed to work by modulating certain physiological processes, although the exact mechanism is unknown.","technicalDetail":"Apronal's mechanism of action is thought to involve interaction with a specific receptor or enzyme, although the exact molecular details are unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3678","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=apronal","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:49:16.139549","biosimilars":[],"competitors":[{"drugName":"scopolamine","drugSlug":"scopolamine","fdaApproval":"1979-12-31","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"propiomazine","drugSlug":"propiomazine","fdaApproval":"1960-12-05","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"triclofos","drugSlug":"triclofos","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"ethchlorvynol","drugSlug":"ethchlorvynol","fdaApproval":"1961-05-10","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dexmedetomidine","drugSlug":"dexmedetomidine","fdaApproval":"1999-12-17","patentExpiry":"Jun 26, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"suvorexant","drugSlug":"suvorexant","fdaApproval":"2014-08-13","patentExpiry":"Nov 20, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"lemborexant","drugSlug":"lemborexant","fdaApproval":"2019-12-20","patentExpiry":"Sep 20, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"apronal","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(3)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"scopolamine","brandName":"scopolamine","genericName":"scopolamine","approvalYear":"1979","relationship":"same-class"},{"drugId":"propiomazine","brandName":"propiomazine","genericName":"propiomazine","approvalYear":"1960","relationship":"same-class"},{"drugId":"triclofos","brandName":"triclofos","genericName":"triclofos","approvalYear":"","relationship":"same-class"},{"drugId":"ethchlorvynol","brandName":"ethchlorvynol","genericName":"ethchlorvynol","approvalYear":"1961","relationship":"same-class"},{"drugId":"dexmedetomidine","brandName":"dexmedetomidine","genericName":"dexmedetomidine","approvalYear":"1999","relationship":"same-class"},{"drugId":"suvorexant","brandName":"suvorexant","genericName":"suvorexant","approvalYear":"2014","relationship":"same-class"},{"drugId":"lemborexant","brandName":"lemborexant","genericName":"lemborexant","approvalYear":"2019","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"V18J24E25E","CHEBI":"CHEBI:134827","UMLSCUI":"C3652934","ChEMBL_ID":"CHEMBL509282","DRUGBANK_ID":"DB13221","PUBCHEM_CID":"10715","MESH_SUPPLEMENTAL_RECORD_UI":"C005700"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"N05CM12","allCodes":["N05CM12"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023 Dec 11","pmid":"37877646","title":"Inhibiting Ion Migration Through Chemical Polymerization and Chemical Chelation Toward Stable Perovskite Solar Cells.","journal":"Angewandte Chemie (International ed. in English)"},{"date":"2016 Nov 16","pmid":"27787985","title":"Sensitive Monitoring of Fluoroquinolones in Milk and Honey Using Multiple Monolithic Fiber Solid-Phase Microextraction Coupled to Liquid Chromatography Tandem Mass Spectrometry.","journal":"Journal of agricultural and food chemistry"},{"date":"1990 Dec","pmid":"2089838","title":"Warning: acetaminophen and aprolidine both labeled Apronal.","journal":"DICP : the annals of pharmacotherapy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Apronal, also known as Isodormid, is a small molecule hypnotic/sedative drug of the ureide group, synthesized in 1926 by Hoffmann-La Roche. It is similar in structure and action to barbiturates, but is considered milder in comparison.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}