{"id":"aprepitant-vs-gabapentin","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Substance P/neurokinin 1 (NK1) receptors are found in the central nervous system and are involved in the transmission of pain and nausea signals. By blocking these receptors, aprepitant reduces the incidence of chemotherapy-induced nausea and vomiting.","oneSentence":"Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist, which blocks the action of substance P, a natural substance in the body that causes nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:28:53.395Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)"},{"name":"Postoperative nausea and vomiting (PONV)"}]},"trialDetails":[{"nctId":"NCT00250744","phase":"PHASE2","title":"Comparison of Aprepitant Versus Gabapentin in the Prevention of Delayed Nausea and Vomiting","status":"COMPLETED","sponsor":"New Mexico Cancer Research Alliance","startDate":"2004-12","conditions":"Cancer","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Aprepitant vs. Gabapentin","genericName":"Aprepitant vs. Gabapentin","companyName":"New Mexico Cancer Research Alliance","companyId":"new-mexico-cancer-research-alliance","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist, which blocks the action of substance P, a natural substance in the body that causes nausea and vomiting. Used for Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV), Postoperative nausea and vomiting (PONV).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}