{"id":"application-of-enamel-matrix-derivatives","safety":{"commonSideEffects":[{"rate":null,"effect":"Local inflammation or swelling at application site"},{"rate":null,"effect":"Temporary discomfort or sensitivity"},{"rate":null,"effect":"Allergic reaction (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Enamel matrix derivatives (EMD) are extracted from developing tooth buds and contain amelogenins and other proteins that guide tissue regeneration. When applied to periodontal defects, these proteins facilitate the recruitment and proliferation of undifferentiated mesenchymal cells, promoting the formation of new cementum, periodontal ligament, and alveolar bone. This biological approach recapitulates the natural healing cascade that occurs during tooth development.","oneSentence":"Enamel matrix derivatives promote periodontal tissue regeneration by mimicking the natural proteins present during tooth development and stimulating the migration and differentiation of periodontal ligament cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:17:44.266Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Periodontal defects and bone loss associated with periodontitis"},{"name":"Guided tissue regeneration in periodontal surgery"}]},"trialDetails":[{"nctId":"NCT07059247","phase":"PHASE4","title":"Periodontal Regeneration at the Distal Site of Second Molars After the Extraction of Lower Included Third Molars","status":"NOT_YET_RECRUITING","sponsor":"Universidad Complutense de Madrid","startDate":"2025-07","conditions":"Tooth Extraction, Wisdom Tooth Removal, Periodontal Regeneration","enrollment":24},{"nctId":"NCT06991998","phase":"NA","title":"Evaluation of Clinical and Radiological Outcomes Following the Treatment of Periodontal Intraosseous Defects Using Autogenous Tooth-derived Graft or Autogenous Bone Graft With Enamel Matrix Derivatives. A 12-month Randomized Controlled Clinical Trial.","status":"ENROLLING_BY_INVITATION","sponsor":"Semmelweis University","startDate":"2024-10-24","conditions":"Periodontitis","enrollment":60},{"nctId":"NCT05442034","phase":"PHASE1, PHASE2","title":"Rh-PDGF vs EMD for Treatment of Intra-bony Defects","status":"RECRUITING","sponsor":"Nova Southeastern University","startDate":"2023-01-01","conditions":"Intrabony Periodontal Defect","enrollment":36},{"nctId":"NCT06250088","phase":"PHASE4","title":"Emdogain Adjunctive to Autotransplantation","status":"RECRUITING","sponsor":"Universidad Complutense de Madrid","startDate":"2024-03-12","conditions":"Autotransplantation, Emdogain, Autologous Transplantation","enrollment":20},{"nctId":"NCT06261255","phase":"NA","title":"Autotransplantation and Enamel Matrix Derivatives Case Series","status":"COMPLETED","sponsor":"Universidad Complutense de Madrid","startDate":"2020-06-01","conditions":"Tooth Loss","enrollment":14},{"nctId":"NCT05456555","phase":"NA","title":"The Flapless Approach in Periodontal Regeneration","status":"COMPLETED","sponsor":"University of Turin, Italy","startDate":"2022-09-01","conditions":"Periodontitis, Adult, Intrabony Periodontal Defect","enrollment":46},{"nctId":"NCT06105112","phase":"NA","title":"Periodontal Regeneration With Hyaluronic Acid or Enamel Matrix Derivatives","status":"RECRUITING","sponsor":"University of Turin, Italy","startDate":"2023-10-01","conditions":"Periodontitis","enrollment":60},{"nctId":"NCT03923465","phase":"NA","title":"Entire Papilla Preservation Technique With and Without Biomaterials in the Treatment of Isolated Intrabony Defects","status":"COMPLETED","sponsor":"Dr. Aslan Private Perio Center","startDate":"2015-04-04","conditions":"Periodontal Diseases","enrollment":30},{"nctId":"NCT05799859","phase":"NA","title":"Treatment of Local Gingival Recession With an Enamel Matrix Protein Coated Collagen Matrix","status":"COMPLETED","sponsor":"Medical University of Graz","startDate":"2017-01-09","conditions":"Gingival Recession","enrollment":15},{"nctId":"NCT04237662","phase":"NA","title":"Enamel Matrix Derivatives & Periodontal Therapy in Diabetic Patients","status":"UNKNOWN","sponsor":"University of Pisa","startDate":"2021-01-01","conditions":"Periodontal Diseases","enrollment":38},{"nctId":"NCT03590093","phase":"NA","title":"Amelogenins and Systemic Inflammation After Periodontal Surgical Therapy","status":"COMPLETED","sponsor":"University of Pisa","startDate":"2013-11-01","conditions":"Periodontal Diseases","enrollment":38},{"nctId":"NCT03544931","phase":"NA","title":"Enamel Matrix Derivatives on Systemic Inflammation After Periodontal Therapy","status":"COMPLETED","sponsor":"University of Pisa","startDate":"2015-12-01","conditions":"Periodontal Diseases","enrollment":38},{"nctId":"NCT03197610","phase":"NA","title":"The Effect of Enamel Matrix Derivatives on Root Coverage Esthetic Score","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2015-01-01","conditions":"Gingival Recession, Periodontal Diseases","enrollment":19}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Application of Enamel Matrix Derivatives","genericName":"Application of Enamel Matrix Derivatives","companyName":"Universidad Complutense de Madrid","companyId":"universidad-complutense-de-madrid","modality":"Biologic","firstApprovalDate":"","aiSummary":"Enamel matrix derivatives promote periodontal tissue regeneration by mimicking the natural proteins present during tooth development and stimulating the migration and differentiation of periodontal ligament cells. Used for Periodontal defects and bone loss associated with periodontitis, Guided tissue regeneration in periodontal surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}