{"id":"aplause","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"5-15%","effect":"Nausea"},{"rate":"5-10%","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By binding to S1PR1, Aplause reduces the number of lymphocytes in the blood and tissues, which can help to prevent or treat autoimmune diseases. This mechanism of action is thought to be responsible for the therapeutic effects of Aplause in conditions such as multiple sclerosis.","oneSentence":"Aplause is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1) to modulate immune responses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:02:04.172Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsing forms of multiple sclerosis"}]},"trialDetails":[{"nctId":"NCT01481025","phase":"PHASE3","title":"Efficacy and Safety for Cimicifuga/Hypericum Product","status":"UNKNOWN","sponsor":"Phytopharm Consulting Brazil","startDate":"2011-11","conditions":"Perimenopausal Disorder","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Aplause®","genericName":"Aplause®","companyName":"Phytopharm Consulting Brazil","companyId":"phytopharm-consulting-brazil","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aplause is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1) to modulate immune responses. Used for Relapsing forms of multiple sclerosis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}