{"id":"apd403-oral","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2108778","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"APD403 is a selective α2δ-1 subunit ligand that modulates the activity of voltage-gated calcium channels. This mechanism is thought to contribute to its analgesic effects. APD403 has been investigated for its potential to reduce the risk of postoperative shivering.","oneSentence":"APD403 is a selective α2δ-1 subunit ligand.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:28:42.065Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of postoperative shivering"}]},"trialDetails":[{"nctId":"NCT01857232","phase":"PHASE2","title":"Dose-finding Study of APD403 to Prevent Nausea and Vomiting After Chemotherapy","status":"COMPLETED","sponsor":"Acacia Pharma Ltd","startDate":"2013-10","conditions":"CINV","enrollment":342}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":824057,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"APD403 oral","genericName":"APD403 oral","companyName":"Acacia Pharma Ltd","companyId":"acacia-pharma-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"APD403 is a selective α2δ-1 subunit ligand. Used for Prevention of postoperative shivering.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}