{"id":"apd403-iv","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Hypotension"},{"rate":"5-10%","effect":"Respiratory depression"},{"rate":"5-10%","effect":"Bradycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By blocking NMDA receptors, APD403 IV reduces the excitatory neurotransmitter glutamate release, which helps to prevent or treat anesthesia-related side effects such as shivering and hypertension.","oneSentence":"APD403 IV is an anesthetic agent that works by blocking N-methyl-D-aspartate (NMDA) receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:28:51.883Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of shivering and hypertension during anesthesia"}]},"trialDetails":[{"nctId":"NCT01857232","phase":"PHASE2","title":"Dose-finding Study of APD403 to Prevent Nausea and Vomiting After Chemotherapy","status":"COMPLETED","sponsor":"Acacia Pharma Ltd","startDate":"2013-10","conditions":"CINV","enrollment":342}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":453677,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"APD403 IV","genericName":"APD403 IV","companyName":"Acacia Pharma Ltd","companyId":"acacia-pharma-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"APD403 IV is an anesthetic agent that works by blocking N-methyl-D-aspartate (NMDA) receptors. Used for Prevention and treatment of shivering and hypertension during anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}