{"id":"apalcillin","rwe":[{"pmid":"11866735","year":"1995","title":"Comparative in vitro activity of apalcillin alone and combined with Ro 48-1220, a novel penam beta-lactamase inhibitor.","finding":"","journal":"Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases","studyType":"Clinical Study"},{"pmid":"8309790","year":"1993","title":"Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines.","finding":"","journal":"Pflugers Archiv : European journal of physiology","studyType":"Clinical Study"},{"pmid":"8490119","year":"1993","title":"Tissue concentration and urinary excretion pattern of sulfofluorescein by the rat kidney.","finding":"","journal":"Journal of the American Society of Nephrology : JASN","studyType":"Clinical Study"},{"pmid":"1921489","year":"1991","title":"The penicillins.","finding":"","journal":"Mayo Clinic proceedings","studyType":"Clinical Study"},{"pmid":"2811057","year":"1989","title":"Contraluminal organic anion and cation transport in the proximal renal tubule: V. Interaction with sulfamoyl- and phenoxy diuretics, and with beta-lactam antibiotics.","finding":"","journal":"Kidney international","studyType":"Clinical Study"}],"tags":[{"label":"apalcillin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:32:59.270997","allNames":["PC-904","apalcillin sodium","apalcillin"],"offLabel":[],"synonyms":["PC-904","apalcillin sodium","apalcillin"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"apalcillin","explanation":"Imagine your body's cells are like buildings, and bacteria are like construction workers. Apalcillin stops the construction workers from building new walls, which eventually causes the building to collapse and die. This is how apalcillin kills bacteria.","oneSentence":"Apalcillin works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death.","technicalDetail":"Apalcillin exerts its antibacterial effect by competitively inhibiting the action of penicillin-binding proteins (PBPs), which are essential for bacterial cell wall synthesis and maintenance."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/227","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=APALCILLIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:48:58.860956","biosimilars":[],"competitors":[],"genericName":"apalcillin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(79)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005976","UNII":"3373RT9U7A","CHEBI":"CHEBI:51691","INN_ID":"4422","UMLSCUI":"C0052145","ChEMBL_ID":"CHEMBL3306902","PUBCHEM_CID":"6602341","IUPHAR_LIGAND_ID":"10759","SECONDARY_CAS_RN":"58795-03-2","MESH_SUPPLEMENTAL_RECORD_UI":"C012122"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.2 hours","clearance":"1.9 mL/min/kg","fractionUnbound":"0.1%","volumeOfDistribution":"0.16 L/kg"},"publicationCount":79,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"1995 Feb","pmid":"11866735","title":"Comparative in vitro activity of apalcillin alone and combined with Ro 48-1220, a novel penam beta-lactamase inhibitor.","journal":"Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"date":"1993 Nov","pmid":"8309790","title":"Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines.","journal":"Pflugers Archiv : European journal of physiology"},{"date":"1993 Feb","pmid":"8490119","title":"Tissue concentration and urinary excretion pattern of sulfofluorescein by the rat kidney.","journal":"Journal of the American Society of Nephrology : JASN"},{"date":"1991 Oct","pmid":"1921489","title":"The penicillins.","journal":"Mayo Clinic proceedings"},{"date":"1989 Jul","pmid":"2811057","title":"Contraluminal organic anion and cation transport in the proximal renal tubule: V. Interaction with sulfamoyl- and phenoxy diuretics, and with beta-lactam antibiotics.","journal":"Kidney international"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"APALCILLIN","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Apalcillin is a small molecule antibiotic in the apalcillin class, but its original developer and current owner are unknown. It has a half-life of 1.2 hours, but its bioavailability and FDA approval status are not specified. Apalcillin's target and approved indications are also unknown. Its commercial status is unclear, but it is not listed as off-patent. Further research is needed to determine its safety and efficacy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}