{"id":"antiviral-agents","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Antiviral agents represent a broad class of drugs that target different stages of the viral life cycle. Depending on the specific agent, they may inhibit viral proteases, reverse transcriptases, neuraminidases, or other essential viral proteins. The exact mechanism depends on the particular antiviral compound being developed by Pregistry in their Phase 3 program.","oneSentence":"Antiviral agents work by inhibiting viral replication through various mechanisms such as blocking viral enzymes, preventing viral entry, or interfering with viral protein synthesis.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:44:12.402Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[]},"trialDetails":[{"nctId":"NCT07371650","phase":"PHASE2","title":"This is an Early-stage Clinical Trial to Determine a Safe and Effective Dose for Tivoxavir Marboxil in Patients With Mild to Moderate Influenza","status":"ACTIVE_NOT_RECRUITING","sponsor":"Traws Pharma, Inc.","startDate":"2025-12-15","conditions":"Influenza","enrollment":105},{"nctId":"NCT07361796","phase":"NA","title":"The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain, Postherpetic Neuralgia","enrollment":832},{"nctId":"NCT06679140","phase":"PHASE3","title":"A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease","status":"RECRUITING","sponsor":"Pfizer","startDate":"2024-12-08","conditions":"COVID-19 SARS-CoV-2 Infection","enrollment":2330},{"nctId":"NCT07493109","phase":"PHASE3","title":"Chidamide for Maintenance Treatment of HBV-infected Diffuse DLBCL in Patients Initially Treated With R-CHOP","status":"RECRUITING","sponsor":"Ou Bai, MD/PHD","startDate":"2026-05-30","conditions":"Diffuse Large B-Cell Lymphoma (DLBCL)","enrollment":200},{"nctId":"NCT07300085","phase":"PHASE1","title":"A Trial to Evaluate the Effect of CD388 on the Immunogenicity of Fluzone® HD Vaccine","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cidara Therapeutics Inc.","startDate":"2025-11-08","conditions":"Healthy Participants","enrollment":100},{"nctId":"NCT02881320","phase":"PHASE2, PHASE3","title":"Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1","status":"ACTIVE_NOT_RECRUITING","sponsor":"Gilead Sciences","startDate":"2016-09-21","conditions":"HIV-1 Infection","enrollment":177},{"nctId":"NCT03520660","phase":"PHASE4","title":"People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2018-10-19","conditions":"Diabetes Mellitus, Hepatitis C, Chronic, Cardiovascular Diseases","enrollment":121},{"nctId":"NCT01581554","phase":"","title":"Withdrawal of Therapy After Long-Term Antiviral Treatment for Chronic Hepatitis B","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2011-05-18","conditions":"Chronic Hepatitis B e Antigen Positive, Chronic Hepatitis B e Antigen Negative","enrollment":15},{"nctId":"NCT07169318","phase":"PHASE1","title":"First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-09-16","conditions":"Influenza","enrollment":78},{"nctId":"NCT03180216","phase":"PHASE1","title":"T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's National Research Institute","startDate":"2017-02-15","conditions":"Viral Infections, Bone Marrow Transplant Infection","enrollment":32},{"nctId":"NCT07392372","phase":"PHASE1","title":"A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV","status":"RECRUITING","sponsor":"BioNTech SE","startDate":"2026-02-09","conditions":"HIV -1 Infection","enrollment":61},{"nctId":"NCT07307170","phase":"NA","title":"The Analgesic Efficacy and Safety of Mirogabalin in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Mirogabalin, Pain","enrollment":750},{"nctId":"NCT07481032","phase":"NA","title":"Effect of Fufang Biejiaruangan Combined With Antiviral Therapy on the Incidence of Hepatocellular Carcinoma in Patients With Hepatitis B-related Cirrhosis: A Multicenter, Randomized, Placebo-controlled Study","status":"NOT_YET_RECRUITING","sponsor":"Nanfang Hospital, Southern Medical University","startDate":"2026-04-01","conditions":"Cirrhosis, Liver, Hepatocellular Carcinoma (HCC), HEPATITIS B CHRONIC","enrollment":1034},{"nctId":"NCT04439916","phase":"","title":"Breakthrough CMV Lung Transplant -Multicentre","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2021-01-25","conditions":"Cytomegalovirus Infections","enrollment":40},{"nctId":"NCT06511063","phase":"PHASE2","title":"Antiviral Clinical Trial for Long Covid-19","status":"RECRUITING","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2024-10-01","conditions":"Long Covid","enrollment":90},{"nctId":"NCT07393685","phase":"","title":"Effectiveness of Xuanfei Jiangzhuo Decoction for Influenza-Induced AECOPD","status":"NOT_YET_RECRUITING","sponsor":"Tianjin Medical University","startDate":"2026-08-01","conditions":"Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Influenza, Human, Virus Diseases","enrollment":300},{"nctId":"NCT07202546","phase":"PHASE2","title":"A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)","status":"RECRUITING","sponsor":"ViiV Healthcare","startDate":"2026-02-11","conditions":"HIV Infections","enrollment":150},{"nctId":"NCT07419373","phase":"PHASE2","title":"ARN-75039 Lassa Fever Treatment in West Africa","status":"RECRUITING","sponsor":"Arisan Therapeutics, Inc.","startDate":"2026-02","conditions":"Lassa Fever","enrollment":135},{"nctId":"NCT07096193","phase":"PHASE1, PHASE2","title":"Study of GS-4321 in Healthy Participants and Participants With Chronic Hepatitis Delta Virus","status":"RECRUITING","sponsor":"Gilead Sciences","startDate":"2025-07-31","conditions":"Chronic Hepatitis Delta","enrollment":107},{"nctId":"NCT05869643","phase":"PHASE2","title":"A Clinical Trial of STP0404 in Adults With HIV-1 Infection","status":"RECRUITING","sponsor":"ST Pharm Co., Ltd.","startDate":"2023-05-23","conditions":"HIV-1-infection","enrollment":36},{"nctId":"NCT06468995","phase":"NA","title":"Antiviral Long Acting Drugs Landing in People Living With HIV","status":"ACTIVE_NOT_RECRUITING","sponsor":"IRCCS San Raffaele","startDate":"2024-12-02","conditions":"HIV, Antiviral Agents","enrollment":120},{"nctId":"NCT05807048","phase":"PHASE2","title":"Daratumumab in STK11 Mutated NSCLC","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2023-06-01","conditions":"Non-small Cell Lung Cancer With STK11/LKB1 Mutation","enrollment":8},{"nctId":"NCT07459426","phase":"","title":"Entecavir Resistance-Associated Mutations in Chronic HBV Patients in Turkey (STREAM Study)","status":"NOT_YET_RECRUITING","sponsor":"Yaşar Bayındır, MD","startDate":"2026-03-15","conditions":"Hepatitis B, Chronic","enrollment":700},{"nctId":"NCT07341386","phase":"PHASE4","title":"Prevention of Recurrence of Herpes Simplex in Autoimmune Rheumatic Diseases","status":"NOT_YET_RECRUITING","sponsor":"University of Sao Paulo General Hospital","startDate":"2026-04-01","conditions":"Autoimmune Rheumatic Diseases, Recurrent Herpes Simplex, Prevention","enrollment":62},{"nctId":"NCT07001319","phase":"PHASE1","title":"Study of GS-3242 in Participants With HIV-1; Substudy-05","status":"RECRUITING","sponsor":"Gilead Sciences","startDate":"2025-05-29","conditions":"HIV-1-infection","enrollment":30},{"nctId":"NCT04648280","phase":"PHASE1, PHASE2","title":"Safety and Pharmacokinetics Evaluation of Fostemsavir + (OBT) in HIV-1 Infected Children and Adolescents Who Are Failing Their cART and Have Dual- or Triple-class Antiretroviral Resistance","status":"ACTIVE_NOT_RECRUITING","sponsor":"PENTA Foundation","startDate":"2022-06-30","conditions":"HIV Infections With Multi Drug Resistant Virus","enrollment":60},{"nctId":"NCT06668025","phase":"NA","title":"MxA-Guided Antiviral Treatment in Respiratory Viral Infections","status":"COMPLETED","sponsor":"Capital Medical University","startDate":"2024-12-12","conditions":"Respiratory Viral Infections, Influenza, SARS CoV-2","enrollment":86},{"nctId":"NCT07450365","phase":"PHASE4","title":"Evaluation of Long-term Efficacy of 4 to 6-month Course Antiviral Therapy for Neurodevelopmental Impairments Caused by Congenital Cytomegalovirus Infection","status":"NOT_YET_RECRUITING","sponsor":"Hu Bofei","startDate":"2026-02-15","conditions":"Congenital CMV Infection","enrollment":150},{"nctId":"NCT07443501","phase":"","title":"Reducing Post-Letermovir CMV Infection: Efficacy of an Immune-Reconstitution-Based Scoring System to Guide Prophylaxis Duration","status":"NOT_YET_RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2026-03-14","conditions":"CMV Infection","enrollment":1114},{"nctId":"NCT02932150","phase":"PHASE2","title":"Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection","status":"RECRUITING","sponsor":"Gilead Sciences","startDate":"2016-11","conditions":"Chronic Hepatitis B","enrollment":150},{"nctId":"NCT06817889","phase":"PHASE2","title":"Remdesivir for the Treatment of Upper Respiratory Tract Infection Due to RSV in Immunocompromised Individuals","status":"RECRUITING","sponsor":"Fred Hutchinson Cancer Center","startDate":"2025-12-23","conditions":"Hematopoietic and Lymphatic System Neoplasm, Autoimmune Disease, Respiratory Syncytial Virus Infection","enrollment":60},{"nctId":"NCT06779058","phase":"","title":"MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B","status":"RECRUITING","sponsor":"Shengjing Hospital","startDate":"2025-01-01","conditions":"Chronic Hepatitis B, Liver Fibrosis","enrollment":600},{"nctId":"NCT07430683","phase":"PHASE4","title":"Valganciclovir Prophylaxis Versus Preemptive Therapy for Cytomegalovirus in Living Donor Kidney Transplant Recipients","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Guadalajara","startDate":"2024-03-01","conditions":"Cytomegalovirus Infections","enrollment":68},{"nctId":"NCT07159763","phase":"PHASE3","title":"A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cidara Therapeutics Inc.","startDate":"2025-09-25","conditions":"Influenza","enrollment":7500},{"nctId":"NCT05587894","phase":"PHASE2","title":"OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial","status":"RECRUITING","sponsor":"ANRS, Emerging Infectious Diseases","startDate":"2023-04-27","conditions":"COVID-19, Immunodeficiency","enrollment":256},{"nctId":"NCT02283112","phase":"","title":"Validation of Drug Assays in Various Biological Matrices","status":"RECRUITING","sponsor":"University of Liverpool","startDate":"2014-10","conditions":"Infection","enrollment":100},{"nctId":"NCT05648448","phase":"PHASE2","title":"A Phase 2 Trial Comparing Antiviral Treatments in Early Symptomatic Influenza","status":"RECRUITING","sponsor":"University of Oxford","startDate":"2023-02-22","conditions":"Influenza, Influenza, Human","enrollment":3000},{"nctId":"NCT05041907","phase":"PHASE2","title":"Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)","status":"RECRUITING","sponsor":"University of Oxford","startDate":"2021-09-30","conditions":"COVID-19","enrollment":3800},{"nctId":"NCT07406217","phase":"PHASE2","title":"OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients","status":"RECRUITING","sponsor":"Calmy Alexandra","startDate":"2023-04-27","conditions":"COVID-19, Immunodeficiency","enrollment":256},{"nctId":"NCT05708508","phase":"PHASE3","title":"Effectiveness of an Immune-guided Cytomegalovirus Infection Preventive Strategy Compared to a Universal Prophylactic Strategy in Renal Transplant Patients","status":"RECRUITING","sponsor":"University Hospital, Rouen","startDate":"2024-03-28","conditions":"Kidney Transplant Infection","enrollment":144},{"nctId":"NCT07235683","phase":"PHASE4","title":"Combination Letermovir and Standard of Care Antiviral for Enhanced Antiviral Response in Cytomegalovirus Infection in Lung Transplant Recipients","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2025-12-24","conditions":"CMV, Lung Transplant Recipient","enrollment":40},{"nctId":"NCT07198139","phase":"PHASE1, PHASE2","title":"A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CDI-988 in Healthy Adults After Challenge With Snow Mountain Virus","status":"RECRUITING","sponsor":"Cocrystal Pharma, Inc.","startDate":"2026-03-01","conditions":"Norovirus","enrollment":40},{"nctId":"NCT07409259","phase":"EARLY_PHASE1","title":"PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure","status":"ACTIVE_NOT_RECRUITING","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2026-01-01","conditions":"Acute-on-Chronic Liver Failure (ACLF)","enrollment":20},{"nctId":"NCT04431245","phase":"","title":"Stopping Antiviral Treatment in Chronic Hepatitis B","status":"ACTIVE_NOT_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2021-06-01","conditions":"Chronic Hepatitis b","enrollment":54},{"nctId":"NCT05334004","phase":"PHASE1","title":"Lopinavir/Ritonavir in PLWH With High-Grade AIN","status":"RECRUITING","sponsor":"University of Wisconsin, Madison","startDate":"2023-12-19","conditions":"High-Grade Anal Intraepithelial Neoplasia","enrollment":21},{"nctId":"NCT06160128","phase":"","title":"Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2022-09-26","conditions":"COVID-19, SARS-CoV-2 Infection, RSV, Influenza","enrollment":400000},{"nctId":"NCT06061536","phase":"PHASE2","title":"Assess the Effectiveness and Safety of Lipovirtide Combined With Nucleoside Drugs in HIV-infected Patients.","status":"COMPLETED","sponsor":"Shanxi Kangbao Biological Product Co., Ltd.","startDate":"2023-11-02","conditions":"HIV","enrollment":64},{"nctId":"NCT07072793","phase":"","title":"A US Study to Look at Loss of Work and Healthcare Costs for People Affected With Mild-to-moderate COVID 19 Who Have High Chances of the Disease Becoming Severe","status":"COMPLETED","sponsor":"Pfizer","startDate":"2024-10-31","conditions":"COVID-19 (Coronavirus Disease 2019)","enrollment":131005},{"nctId":"NCT05532293","phase":"PHASE1","title":"Phase One Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of MSP008-22 in Healthy Adult Volunteers","status":"COMPLETED","sponsor":"Godavari Biorefineries Limited","startDate":"2022-12-02","conditions":"COVID-19","enrollment":64},{"nctId":"NCT05856890","phase":"PHASE1","title":"HepB mAb19 in Individuals With Chronic Hepatitis B Infection","status":"RECRUITING","sponsor":"Rockefeller University","startDate":"2023-08-07","conditions":"Hepatitis b Virus, Hepatitis B","enrollment":37},{"nctId":"NCT07378046","phase":"NA","title":"The Analgesic Efficacy and Safety of Baclofen in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT07378059","phase":"NA","title":"The Analgesic Efficacy and Safety of Loxoprofen Sodium Patch in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT01651403","phase":"PHASE3","title":"Study to Evaluate the Antiviral Efficacy, Safety and Tolerability of Tenofovir Disoproxil Fumarate Versus Placebo in Pediatric Participants With Chronic Hepatitis B Infection","status":"ACTIVE_NOT_RECRUITING","sponsor":"Gilead Sciences","startDate":"2012-12-06","conditions":"Chronic Hepatitis B","enrollment":90},{"nctId":"NCT04605679","phase":"NA","title":"Hepatitis C Virus (HCV) Positive Kidney Grafts in HCV Negative Recipients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Loma Linda University","startDate":"2020-05-06","conditions":"Kidney Failure","enrollment":31},{"nctId":"NCT01199562","phase":"","title":"Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant","status":"ACTIVE_NOT_RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2010-12","conditions":"Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia","enrollment":153},{"nctId":"NCT07370402","phase":"NA","title":"The Analgesic Efficacy and Safety of Flurbiprofen Patch in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT07370389","phase":"NA","title":"The Analgesic Efficacy and Safety of Tulodesvenlafaxine in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT07090759","phase":"PHASE3","title":"To Evaluate the Efficacy, Safety and Population Pharmacokinetics of GST-HG141 in Patients With Chronic Hepatitis B (CHB) Who Have an Inadequate Response to Antiviral Drug Treatment","status":"RECRUITING","sponsor":"Fujian Akeylink Biotechnology Co., Ltd.","startDate":"2025-07-24","conditions":"Chronic Hepatitis b","enrollment":526},{"nctId":"NCT07363031","phase":"PHASE2","title":"Oral Herpesviruses and Oral Mucositis in Patients Receiving Head and Neck Radiotherapy","status":"ENROLLING_BY_INVITATION","sponsor":"Instituto Oncoclinicas","startDate":"2022-09-05","conditions":"Oral Mucositis, Head and Neck Cancer (H&N), Radiotherapy Side Effects","enrollment":84},{"nctId":"NCT07361809","phase":"NA","title":"The Analgesic Efficacy and Safety of Desvenlafaxine in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT04707820","phase":"NA","title":"Antiviral T Lymphocyte Immunity During Acute COVID-19 Infection","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2020-04-16","conditions":"Corona Virus Infection","enrollment":51},{"nctId":"NCT07344246","phase":"NA","title":"Efficacy and Safety of Intravenous Dexamethasone Palmitate Treatments in Acute and Subacute Herpes Zoster Pain","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-02-01","conditions":"Herpes Zoster Pain","enrollment":954},{"nctId":"NCT07307976","phase":"NA","title":"The Analgesic Efficacy and Safety of Crisugabalin in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT06532656","phase":"PHASE2, PHASE3","title":"Study of Bictegravir/Lenacapavir in Children and Adolescents With HIV-1","status":"RECRUITING","sponsor":"Gilead Sciences","startDate":"2024-11-20","conditions":"HIV-1-infection","enrollment":75},{"nctId":"NCT02797522","phase":"PHASE1","title":"A Study of ARC-521 Injection in Normal Adult Volunteers and Patients With Chronic Hepatitis B (CHB)","status":"TERMINATED","sponsor":"Arrowhead Pharmaceuticals","startDate":"2016-06","conditions":"Hepatitis B","enrollment":47},{"nctId":"NCT07329686","phase":"PHASE1, PHASE2","title":"Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2025-10-01","conditions":"Herpes Simplex Keratitis, Corneal Neovascularization","enrollment":100},{"nctId":"NCT01854775","phase":"PHASE2, PHASE3","title":"Study to Evaluate the Pharmacokinetics, Safety, and Antiviral Activity of the Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Single Tablet Regimen (STR) in HIV-1 Infected Antiretroviral Treatment-Naive Adolescents and Virologically Suppressed Children","status":"COMPLETED","sponsor":"Gilead Sciences","startDate":"2013-05-06","conditions":"Acquired Immune Deficiency Syndrome (AIDS), HIV Infections","enrollment":129},{"nctId":"NCT05999435","phase":"PHASE2, PHASE3","title":"Study of LAU-7b for the Treatment of Long COVID in Adults","status":"COMPLETED","sponsor":"Laurent Pharmaceuticals Inc.","startDate":"2023-11-15","conditions":"Long COVID","enrollment":272},{"nctId":"NCT06999603","phase":"PHASE2","title":"Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection","status":"RECRUITING","sponsor":"Synairgen Research Ltd.","startDate":"2025-09-02","conditions":"Viral Pneumonia","enrollment":550},{"nctId":"NCT04453917","phase":"NA","title":"Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2021-02-23","conditions":"Progressive Multifocal Leukoencephalopathy","enrollment":22},{"nctId":"NCT06993480","phase":"PHASE2","title":"A Study to Evaluate the Antiviral Activity and Immune Response of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB)","status":"RECRUITING","sponsor":"Ausper Biopharma Co., Ltd.","startDate":"2025-06-18","conditions":"Chronic Hepatitis B","enrollment":30},{"nctId":"NCT02349126","phase":"PHASE2","title":"Study of ARC-520 in Patient With Chronic Hepatitis B Virus","status":"WITHDRAWN","sponsor":"Arrowhead Pharmaceuticals","startDate":"2015-02","conditions":"Chronic Hepatitis B","enrollment":""},{"nctId":"NCT07225959","phase":"PHASE2","title":"A Study to Evaluate the Safety, Pharmacokinetics, and Occurrence of Anti-Drug Antibodies Following Annual Doses of CD388","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cidara Therapeutics Inc.","startDate":"2025-10-29","conditions":"Healthy Participants","enrollment":400},{"nctId":"NCT07295873","phase":"PHASE1","title":"Drug-Drug Interaction Study Between Hydronidone and Entecavir, Tenofovir Disoproxil Fumarate, Tenofovir Alafenamide, and Tenofovir Amibufenamide","status":"NOT_YET_RECRUITING","sponsor":"Beijing Continent Pharmaceutical Co, Ltd.","startDate":"2025-12-30","conditions":"Chronic Hepatitis B Liver Fibrosis, DDI (Drug-Drug Interaction)","enrollment":64},{"nctId":"NCT06958796","phase":"PHASE4","title":"Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)","status":"RECRUITING","sponsor":"Camille N. Kotton, MD","startDate":"2025-11-27","conditions":"Cytomegalovirus, Organ Transplant, Kidney Transplant; Complications","enrollment":80},{"nctId":"NCT06562803","phase":"NA","title":"Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis","status":"RECRUITING","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2024-09-27","conditions":"Acute-On-Chronic Liver Failure, Sepsis","enrollment":60},{"nctId":"NCT05195060","phase":"","title":"TURN-COVID Biobank: The Dutch Cohort Study for the Evaluation of the Use of Neutralizing Monoclonal Antibodies and Other Antiviral Agents Against SARS-CoV-2","status":"COMPLETED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2021-12-14","conditions":"COVID-19","enrollment":1178},{"nctId":"NCT05381454","phase":"PHASE1, PHASE2","title":"An Open Label Study in Adults to Test the Efficacy of Mitoquinone/Mitoquinol Mesylate to Prevent Severe Viral Illness","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2022-04-28","conditions":"Respiratory Viral Infection, Antiviral Treatment, COVID-19","enrollment":80},{"nctId":"NCT04690933","phase":"","title":"AntiCMV molécules Monitoring in Real-life in Stem Cell Recipients","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2020-09-24","conditions":"Hematopoietic Stem Cell Transplantation, Cytomegalovirus Infections, Antivirals","enrollment":400},{"nctId":"NCT07016321","phase":"PHASE2, PHASE3","title":"Emetine for Viral Outbreaks (a.k.a. EVOLVE Antiviral Initiative)","status":"NOT_YET_RECRUITING","sponsor":"Johns Hopkins University","startDate":"2026-05-01","conditions":"Dengue","enrollment":600},{"nctId":"NCT07274345","phase":"","title":"Prevalence and Risk Factors of Antiviral Resistance in Egyptian HBV Patients","status":"NOT_YET_RECRUITING","sponsor":"Amira Mohamed Zidan","startDate":"2025-12-01","conditions":"Chronic Hepatitis B - Antiviral Drug Resistance - Hepatitis B Virus (HBV) Infection","enrollment":2000},{"nctId":"NCT06749054","phase":"PHASE2","title":"Evaluation of Long-Acting Lenacapavir for the Treatment of HIV-1 in Treatment-experienced Adolescents and Children","status":"RECRUITING","sponsor":"Gilead Sciences","startDate":"2025-03-26","conditions":"HIV-1-infection","enrollment":12},{"nctId":"NCT05595369","phase":"PHASE2","title":"RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms","status":"COMPLETED","sponsor":"Kanecia Obie Zimmerman","startDate":"2023-07-26","conditions":"Long COVID, Long Covid19","enrollment":963},{"nctId":"NCT06385327","phase":"PHASE1","title":"A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-5366 in Healthy Participants and Participants Seropositive for HSV-2 With Recurrent Genital Herpes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Assembly Biosciences","startDate":"2024-05-30","conditions":"Recurrent Genital Herpes Simplex Type 2","enrollment":115},{"nctId":"NCT02539407","phase":"","title":"Population Pharmacokinetics of Anti-infectives in Critically Ill Children","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2015-09-11","conditions":"Pediatric Intensive Care Unit, Pediatric Immuno-hematology Department","enrollment":3000},{"nctId":"NCT05797714","phase":"NA","title":"The Effectiveness and Safety of TMF in the Treatment of Chronic Hepatitis B Patients With Normal ALT.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ruijin Hospital","startDate":"2022-06-08","conditions":"HBV Infection, Chronic Hepatitis b","enrollment":200},{"nctId":"NCT04417257","phase":"PHASE2, PHASE3","title":"Study of LAU-7b for the Treatment of Coronavirus Disease 2019 (COVID-19) Disease in Adults","status":"TERMINATED","sponsor":"Laurent Pharmaceuticals Inc.","startDate":"2020-08-18","conditions":"COVID-19 Disease","enrollment":351},{"nctId":"NCT06987318","phase":"PHASE1","title":"A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection","status":"NOT_YET_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2026-02-15","conditions":"HIV-1-infection","enrollment":40},{"nctId":"NCT07225972","phase":"PHASE3","title":"Phase 3 Randomized Trial for Refractory ADV or CMV Infection With Family Matched CTLs and Standard of Care (SOC) vs SOC Alone","status":"NOT_YET_RECRUITING","sponsor":"New York Medical College","startDate":"2026-12-01","conditions":"CMV, AdV Infection, AdV Reactivation","enrollment":69},{"nctId":"NCT05484895","phase":"NA","title":"Mobile Health Intervention to Increase HIV Testing and Linkage to Care","status":"COMPLETED","sponsor":"Emory University","startDate":"2021-12-15","conditions":"HIV","enrollment":1800},{"nctId":"NCT05957913","phase":"PHASE2","title":"Effects of Antiviral Therapies on Epstein-Barr Virus Replication","status":"ENROLLING_BY_INVITATION","sponsor":"Massachusetts General Hospital","startDate":"2023-06-05","conditions":"Multiple Sclerosis","enrollment":50},{"nctId":"NCT05275998","phase":"PHASE1, PHASE2","title":"TMB-365 and TMB-380 in Suppressed HIV-1 Infected Individuals","status":"COMPLETED","sponsor":"TaiMed Biologics Inc.","startDate":"2022-07-05","conditions":"HIV-1-infection","enrollment":51},{"nctId":"NCT07115368","phase":"PHASE1","title":"Study of GS-1219 in Participants With HIV-1","status":"TERMINATED","sponsor":"Gilead Sciences","startDate":"2025-08-11","conditions":"HIV-1-infection","enrollment":4},{"nctId":"NCT06061081","phase":"PHASE2","title":"A Study to Investigate the Antiviral Effect, Safety, Tolerability and Pharmacokinetics of VH3739937 in in Treatment-Naive Adults Living With HIV-1","status":"TERMINATED","sponsor":"ViiV Healthcare","startDate":"2023-12-21","conditions":"HIV Infections","enrollment":21},{"nctId":"NCT06609460","phase":"PHASE2","title":"Study of CD388 for the Prevention of Influenza in Subjects Not at Risk for Influenza Complications","status":"COMPLETED","sponsor":"Cidara Therapeutics Inc.","startDate":"2024-09-20","conditions":"Influenza","enrollment":5071},{"nctId":"NCT05618925","phase":"PHASE1","title":"Study for Subjects With Relapsed/Refractory Non- Hodgkin Lymphoma","status":"RECRUITING","sponsor":"ImmunityBio, Inc.","startDate":"2025-08-22","conditions":"Non Hodgkin's Lymphoma Refractory/Relapsed","enrollment":20},{"nctId":"NCT04704024","phase":"PHASE3","title":"Reducing Vertical Transmission of Hepatitis B in Africa","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2021-09-03","conditions":"Hepatitis B Infection","enrollment":450},{"nctId":"NCT06170242","phase":"PHASE2","title":"A Controlled Phase 2a Study to Evaluate the Efficacy of EDP-323 Against Respiratory Syncytial Virus Infection in a Virus Challenge Model","status":"COMPLETED","sponsor":"Enanta Pharmaceuticals, Inc","startDate":"2023-11-20","conditions":"RSV Infection","enrollment":142},{"nctId":"NCT04896255","phase":"","title":"Long-term Outcomes of Anti-viral Therapies in Patients With Chronic Viral Hepatitis B","status":"RECRUITING","sponsor":"Huashan Hospital","startDate":"2020-09-09","conditions":"Chronic Hepatitis b","enrollment":33000},{"nctId":"NCT04782375","phase":"PHASE4","title":"Safely Discontinue Antiviral Treatment in Patients With Chronic Hepatitis B","status":"ACTIVE_NOT_RECRUITING","sponsor":"Asan Medical Center","startDate":"2021-09-01","conditions":"Hepatitis B, Chronic","enrollment":140}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"BLOOD ALKALINE PHOSPHATASE INCREASED"},{"count":2,"reaction":"NAUSEA"},{"count":2,"reaction":"SOMNOLENCE"},{"count":1,"reaction":"ADRENAL INSUFFICIENCY"},{"count":1,"reaction":"ALBUMINURIA"},{"count":1,"reaction":"ANAEMIA"},{"count":1,"reaction":"BLOOD UREA DECREASED"},{"count":1,"reaction":"DEHYDRATION"},{"count":1,"reaction":"DIABETES MELLITUS"},{"count":1,"reaction":"DIARRHOEA"}],"_approvalHistory":[],"publicationCount":11366,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Veklury (remdesivir)","Lagevrio (molnupiravir)","Nucleoside analogue","Nucleotide analogue","Peginterferon"],"phase":"phase_3","status":"active","brandName":"Antiviral Agents","genericName":"Antiviral Agents","companyName":"Pregistry","companyId":"pregistry","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}