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The specific mechanism depends on the particular antihypertensive agent(s) used in the treatment regimen.","oneSentence":"Antihypertensive treatment lowers blood pressure through one or more mechanisms such as vasodilation, reduced cardiac output, or decreased peripheral vascular resistance.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:17:26.897Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension (essential or secondary)"}]},"trialDetails":[{"nctId":"NCT07495267","phase":"NA","title":"Nutritional Ketosis Marfan","status":"NOT_YET_RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2026-03-13","conditions":"Marfan Syndrome, Aortic Dissection","enrollment":15},{"nctId":"NCT05163158","phase":"NA","title":"CENtral Blood Pressure Targeting: A Pragmatic RAndomized Pilot triaL in Advanced Chronic Kidney Disease","status":"COMPLETED","sponsor":"Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal","startDate":"2022-05-24","conditions":"Chronic Kidney Diseases, Hypertension","enrollment":116},{"nctId":"NCT06059638","phase":"NA","title":"BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT","status":"RECRUITING","sponsor":"Orchestra BioMed, Inc","startDate":"2023-12-27","conditions":"Hypertension, Hypertension, Systolic, Hypertension, Essential","enrollment":500},{"nctId":"NCT06108427","phase":"NA","title":"REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study","status":"RECRUITING","sponsor":"Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal","startDate":"2024-04-25","conditions":"Primary Aldosteronism","enrollment":58},{"nctId":"NCT04789733","phase":"NA","title":"The GUARDIAN Pilot Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2021-04-27","conditions":"General Surgery","enrollment":80},{"nctId":"NCT07475949","phase":"PHASE3","title":"Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging","status":"NOT_YET_RECRUITING","sponsor":"First Affiliated Hospital of Guangxi Medical University","startDate":"2026-04","conditions":"Acute Ischemic Stroke, Tenecteplase","enrollment":352},{"nctId":"NCT07475936","phase":"","title":"Intravenous Tenecteplase in Very Old Patients With Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"First Affiliated Hospital of Guangxi Medical University","startDate":"2026-04","conditions":"Acute Ischemic Stroke, Tenecteplase","enrollment":392},{"nctId":"NCT07469800","phase":"PHASE3","title":"Efficacy and Safety of IBI362 in Hypertensive Patients With Overweight/Obesity","status":"NOT_YET_RECRUITING","sponsor":"Innovent Biologics (Suzhou) Co. 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