{"id":"antibiotic-oral-suppressive-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Photosensitivity (if fluoroquinolone-based)"},{"rate":null,"effect":"Yeast infection/candidiasis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This therapeutic approach involves chronic administration of oral antibiotics at sub-therapeutic doses to suppress the growth of pathogenic bacteria and reduce the risk of recurrent infections. It is commonly used in patients with recurrent urinary tract infections, chronic prostatitis, or other conditions prone to bacterial recurrence. The mechanism relies on maintaining suppressive antibiotic levels in tissues and body fluids to prevent bacterial colonization and infection.","oneSentence":"Antibiotic oral suppressive therapy uses low-dose antibiotics taken orally over an extended period to prevent recurrent bacterial infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:37.276Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Recurrent urinary tract infections (prophylaxis)"},{"name":"Recurrent bacterial infections (suppressive therapy)"}]},"trialDetails":[{"nctId":"NCT05495815","phase":"NA","title":"Proper Duration of Suppressive Antibiotic Therapy After Debridement, Antibiotics, and Implant Retention","status":"WITHDRAWN","sponsor":"University of Maryland, Baltimore","startDate":"2024-12","conditions":"Periprosthetic Joint Infection, Antibiotic Suppression","enrollment":""},{"nctId":"NCT05640336","phase":"NA","title":"Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression","status":"ENROLLING_BY_INVITATION","sponsor":"Mayo Clinic","startDate":"2023-03-03","conditions":"Periprosthetic Joint Infection","enrollment":490},{"nctId":"NCT07274020","phase":"PHASE3","title":"Long-Term Safety and Efficacy of Moxifloxacin in Bronchiectasis Patients","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-12-01","conditions":"Bronchiectasis, Non-Cystic Fibrosis","enrollment":140},{"nctId":"NCT05033743","phase":"PHASE2, PHASE3","title":"Suppressive Antibacterial Therapy With Once-Weekly Secnidazole Granules to Prevent Recurrent Bacterial Vaginosis; A Pilot Study","status":"COMPLETED","sponsor":"Indiana University","startDate":"2021-07-09","conditions":"Recurrent Bacterial Vaginosis","enrollment":24},{"nctId":"NCT04285320","phase":"PHASE4","title":"Antibiotic Bladder Instillations vs. Oral Suppression for the Treatment of Recurrent Urinary Tract Infections","status":"UNKNOWN","sponsor":"Atlantic Health System","startDate":"2021-03","conditions":"Recurrent Urinary Tract Infection","enrollment":100},{"nctId":"NCT02569541","phase":"PHASE2, PHASE3","title":"Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections","status":"COMPLETED","sponsor":"Arrevus Inc.","startDate":"2015-12","conditions":"Refractory Bone or Joint Infections","enrollment":30},{"nctId":"NCT01450800","phase":"PHASE4","title":"Suppressive Therapy With Oral Antibiotics for Prevention of Postoperative Urinary Tract Infection (UTI)","status":"COMPLETED","sponsor":"Duke University","startDate":"2011-08","conditions":"Urinary Tract Infection","enrollment":163}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Antibiotic oral suppressive therapy","genericName":"Antibiotic oral suppressive therapy","companyName":"Atlantic Health System","companyId":"atlantic-health-system","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Antibiotic oral suppressive therapy uses low-dose antibiotics taken orally over an extended period to prevent recurrent bacterial infections. Used for Recurrent urinary tract infections (prophylaxis), Recurrent bacterial infections (suppressive therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}