{"id":"antibiotic-lock","safety":{"commonSideEffects":[{"rate":null,"effect":"Local catheter site reactions"},{"rate":null,"effect":"Thrombosis"},{"rate":null,"effect":"Catheter dysfunction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"An antibiotic lock solution is instilled into the catheter lumen between uses, where it remains in contact with the catheter surface and any biofilm that may have formed. This local, high-concentration approach prevents bacterial colonization and biofilm formation on central venous catheters, reducing the risk of catheter-related infections without systemic antibiotic exposure.","oneSentence":"Antibiotic lock therapy delivers high concentrations of antibiotics directly into a catheter lumen to prevent and treat catheter-related bloodstream infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:17:18.903Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of catheter-related bloodstream infections in patients with central venous catheters"},{"name":"Treatment of catheter-related bloodstream infections"}]},"trialDetails":[{"nctId":"NCT07019610","phase":"NA","title":"Chlorhexidine Caps for CLABSI Prevention in Hemodialysis: a Pilot Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"The University of Queensland","startDate":"2026-03","conditions":"Vascular Access Complication, Device Related Infection, Device Related Sepsis","enrollment":60},{"nctId":"NCT05879835","phase":"NA","title":"KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure","status":"RECRUITING","sponsor":"SterileCare Inc.","startDate":"2024-06-21","conditions":"Pediatric Intestinal Failure","enrollment":124},{"nctId":"NCT06799494","phase":"PHASE4","title":"HPV Vaccine Reduced Dose","status":"RECRUITING","sponsor":"Emory University","startDate":"2025-08-06","conditions":"HPV","enrollment":100},{"nctId":"NCT07074821","phase":"PHASE2","title":"Antimicrobial Locks for Hemodialysis Catheter Infections","status":"COMPLETED","sponsor":"Oman Ministry of Health","startDate":"2023-03-01","conditions":"Catheter Related Blood Stream Infection, Hemodialysis, Vascular Access","enrollment":100},{"nctId":"NCT06968754","phase":"NA","title":"The Impact of Pharmaceutical Care on the Infection Control Measures Among Hemodialytic Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Sulaimani","startDate":"2024-11-01","conditions":"Infection, Hemodialysis Patients","enrollment":90},{"nctId":"NCT06949176","phase":"NA","title":"Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal","status":"ACTIVE_NOT_RECRUITING","sponsor":"National and Kapodistrian University of Athens","startDate":"2023-12-01","conditions":"Apical Periodontitis, Root Canal Infection","enrollment":44},{"nctId":"NCT04789928","phase":"PHASE1","title":"Conservative Treatment of Catheter - Related Injections With Gentamicine/EDTA","status":"COMPLETED","sponsor":"Institut Pasteur","startDate":"2021-01-05","conditions":"Patients With Uncomplicated Long-term Central Venous Catheter-related Biofilm-related Infection","enrollment":8},{"nctId":"NCT05971537","phase":"PHASE4","title":"Clinical Trial on Antibiotic-Lock in Tenckhoff Catheter for Relasping and Repeat Peritonitis","status":"RECRUITING","sponsor":"Alice Ho Miu Ling Nethersole Hospital","startDate":"2023-06-15","conditions":"Peritoneal Dialysis-associated Peritonitis","enrollment":46},{"nctId":"NCT02901717","phase":"PHASE3","title":"Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI","status":"UNKNOWN","sponsor":"Leonard-Meron Biosciences, Inc.","startDate":"2018-02-13","conditions":"Catheter-related Infections","enrollment":144},{"nctId":"NCT00571259","phase":"PHASE4","title":"Prophylactic Antimicrobial Catheter Lock","status":"COMPLETED","sponsor":"Satellite Healthcare","startDate":"2003-09","conditions":"Bacteremia","enrollment":303},{"nctId":"NCT01472965","phase":"PHASE3","title":"Ethanol Lock Therapy for Treatment and Secondary Prophylaxis of Central Line-Associated Bloodstream Infection","status":"COMPLETED","sponsor":"St. Jude Children's Research Hospital","startDate":"2011-12-29","conditions":"Central Line-Associated Bloodstream Infection","enrollment":95},{"nctId":"NCT02577718","phase":"PHASE1, PHASE2","title":"Safety and Effectiveness of Novel Nitroglycerin Based Catheter Lock Solution","status":"COMPLETED","sponsor":"Novel Anti-Infective Technologies, LLC","startDate":"2015-11","conditions":"Catheter-Associated Infections, Catheter-Related Infections","enrollment":60},{"nctId":"NCT01989091","phase":"PHASE3","title":"Efficacy Study to Evaluate B-Lock™ as an Antimicrobial Lock Solution in Dialysis Patients With a CVC","status":"TERMINATED","sponsor":"Great Lakes Pharmaceuticals Inc.","startDate":"2012-07","conditions":"Dialysis Catheter Infections","enrollment":270},{"nctId":"NCT01539343","phase":"PHASE2","title":"Antimicrobial Catheter Lock Solution for the Treatment of Central Line Associated Bloodstream Infection (CLABSI)","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2013-04","conditions":"Infection","enrollment":31},{"nctId":"NCT01948245","phase":"PHASE4","title":"Clinical Trial Comparing Catheter Lock Solutions TaurolockTMHep 100 and Heparin 100 IE/ml.","status":"UNKNOWN","sponsor":"Palle Bekker Jeppesen","startDate":"2013-10","conditions":"Catheter-related Bloodstream Infection (CRBSI) Nos","enrollment":42},{"nctId":"NCT02040818","phase":"PHASE2, PHASE3","title":"Treatment of Hemodialysis Catheter-Related Bacteremia","status":"WITHDRAWN","sponsor":"University of California, San Diego","startDate":"2013-11","conditions":"Hemodialysis Catheter-related Bacteremia","enrollment":""},{"nctId":"NCT01592032","phase":"PHASE4","title":"Concentration of Antimicrobials in Catheter-lock Solutions","status":"UNKNOWN","sponsor":"Clinica Universidad de Navarra, Universidad de Navarra","startDate":"2012-05","conditions":"Catheter-Related Infections, Bacteremia.","enrollment":125},{"nctId":"NCT01101412","phase":"PHASE1, PHASE2","title":"Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies","status":"WITHDRAWN","sponsor":"M.D. Anderson Cancer Center","startDate":"","conditions":"Chronic Myeloproliferative Disorders, Infection, Leukemia","enrollment":""},{"nctId":"NCT01186172","phase":"PHASE3","title":"Ethanol Lock for the Salvage of Infected Long-term Vascular Access","status":"UNKNOWN","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2010-06","conditions":"Bacteremia","enrollment":200},{"nctId":"NCT00809887","phase":"PHASE1","title":"Micafungin Lock Therapy","status":"TERMINATED","sponsor":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","startDate":"2006-06","conditions":"Catheter-Related Fungal Infections","enrollment":20},{"nctId":"NCT00294502","phase":"PHASE4","title":"Antibiotic Lock Solutions in the Prevention of Catheter Related Bacteremia","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2003-09","conditions":"ESRD","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":303,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Standard of Care antibiotics with antibiotic lock"],"phase":"marketed","status":"active","brandName":"antibiotic lock","genericName":"antibiotic lock","companyName":"Alice Ho Miu Ling Nethersole Hospital","companyId":"alice-ho-miu-ling-nethersole-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Antibiotic lock therapy delivers high concentrations of antibiotics directly into a catheter lumen to prevent and treat catheter-related bloodstream infections. Used for Prevention of catheter-related bloodstream infections in patients with central venous catheters, Treatment of catheter-related bloodstream infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}