{"id":"antibiotic-amoxicillin","safety":{"commonSideEffects":[{"rate":"5–10%","effect":"Diarrhea"},{"rate":"3–5%","effect":"Nausea"},{"rate":"1–3%","effect":"Rash"},{"rate":"0.1–1%","effect":"Allergic reaction / Anaphylaxis"},{"rate":"1–3%","effect":"Vomiting"},{"rate":"1–2%","effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amoxicillin is a beta-lactam antibiotic that penetrates bacterial cell walls and irreversibly binds to penicillin-binding proteins (PBPs), preventing the cross-linking of peptidoglycan strands. This disrupts cell wall integrity, leading to bacterial cell lysis and death. It is bactericidal and effective against a broad spectrum of gram-positive and some gram-negative bacteria.","oneSentence":"Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and blocking peptidoglycan cross-linking.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:02:00.456Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections (respiratory tract, urinary tract, skin and soft tissue, otitis media, sinusitis)"},{"name":"Helicobacter pylori eradication (as part of combination therapy)"}]},"trialDetails":[{"nctId":"NCT07498556","phase":"NA","title":"Immediate Restoration of a New Implant With High Primary Stability","status":"NOT_YET_RECRUITING","sponsor":"Universidade do Porto","startDate":"2026-03-01","conditions":"Dental Implants, Immediate Dental Implant Loading","enrollment":50},{"nctId":"NCT07492134","phase":"PHASE2","title":"APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)","status":"NOT_YET_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2026-04-01","conditions":"Acute Uncomplicated Diverticulitis","enrollment":100},{"nctId":"NCT05761080","phase":"PHASE4","title":"Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics","status":"RECRUITING","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2021-04-22","conditions":"Laparoscopic Appendectomy, Complicated Appendicitis, Periappendicular Abscess","enrollment":772},{"nctId":"NCT07485010","phase":"PHASE2","title":"Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial","status":"NOT_YET_RECRUITING","sponsor":"The University of Queensland","startDate":"2027-04","conditions":"Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection, Non-Tuberculous Mycobacterial (NTM) Infections","enrollment":300},{"nctId":"NCT06406114","phase":"PHASE2","title":"Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-05-05","conditions":"Drug Allergy, Cephalosporin Allergy, Drug Hypersensitivity","enrollment":300},{"nctId":"NCT05444439","phase":"NA","title":"Antibiotyping and Prevalence of Virulent Genotypes Among Helicobacter Pylori and Their Impact on Response to Therapy","status":"COMPLETED","sponsor":"Assiut University","startDate":"2024-01-20","conditions":"H Pylori Infection","enrollment":100},{"nctId":"NCT05834036","phase":"PHASE4","title":"Effect of Antibiotics on Enteric Neurons and Glia","status":"COMPLETED","sponsor":"Rockefeller University","startDate":"2023-06-23","conditions":"Antibiotic Enterocolitis","enrollment":10},{"nctId":"NCT06080698","phase":"NA","title":"Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2024-02-22","conditions":"Gram-negative Bacteremia","enrollment":1030},{"nctId":"NCT07455448","phase":"","title":"Antibiotic Resistance of Helicobacter Pylori in Nanjing: A Cross-Sectional Study","status":"NOT_YET_RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2026-03","conditions":"HELICOBACTER PYLORI INFECTIONS","enrollment":7228},{"nctId":"NCT07451171","phase":"PHASE2","title":"Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children","status":"NOT_YET_RECRUITING","sponsor":"University of Virginia","startDate":"2026-04","conditions":"Small Intestine Bacterial Overgrowth","enrollment":60},{"nctId":"NCT06076304","phase":"PHASE4","title":"Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis","status":"RECRUITING","sponsor":"Daniel Merenstein","startDate":"2023-11-21","conditions":"Sinus Infection, Acute Sinusitis","enrollment":3720},{"nctId":"NCT06494072","phase":"PHASE4","title":"Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP","status":"RECRUITING","sponsor":"Medical College of Wisconsin","startDate":"2024-08-22","conditions":"Community Acquired Pneumonia in Children","enrollment":236},{"nctId":"NCT05398679","phase":"PHASE4","title":"Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis","status":"RECRUITING","sponsor":"Fundacion Clinic per a la Recerca Biomédica","startDate":"2022-08-17","conditions":"Endocarditis Infective","enrollment":360},{"nctId":"NCT07202949","phase":"PHASE2","title":"A Clinical Trial of Extended (High) Treatment Dose Antibiotics in Combination With Methenamine Hippurate Compared to the Standard of Care (Either Prophylactic (Low) Dose Antibiotic Treatment or Methenamine Hippurate) in Females With Chronic Urinary Tract Infection","status":"NOT_YET_RECRUITING","sponsor":"University College, London","startDate":"2026-02-28","conditions":"Chronic Urinary Tract Infection","enrollment":192},{"nctId":"NCT07099976","phase":"NA","title":"PromotIng Optimal Treatment for Community-acquired PNeumonia in EmErgency Rooms","status":"NOT_YET_RECRUITING","sponsor":"Jeffrey Pernica","startDate":"2026-03-15","conditions":"Community-Acquired Pneumonia (CAP), Pneumonia","enrollment":698},{"nctId":"NCT07408271","phase":"","title":"The Impact of Helicobacter Pylori Eradication on the Vaginal Microecology Change","status":"COMPLETED","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2023-03-24","conditions":"Helicobacter Pylori Infection, Helicobacter Pylori Eradication Antibiotic","enrollment":83},{"nctId":"NCT07293910","phase":"PHASE2","title":"Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection","status":"RECRUITING","sponsor":"Tanta University","startDate":"2026-02-15","conditions":"HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection, Helicobacter Pylori Gastrointestinal Tract Infection","enrollment":66},{"nctId":"NCT06537609","phase":"NA","title":"A Platform Trial for Gram Negative Bloodstream Infections","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2024-04-24","conditions":"Gram-negative Bacteremia","enrollment":2500},{"nctId":"NCT05100654","phase":"EARLY_PHASE1","title":"Collaborative Urological Prosthetics Investigation Directive Research Group","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Chicago","startDate":"2022-04-22","conditions":"Erectile Dysfunction, Penile Prosthesis Infection","enrollment":800},{"nctId":"NCT07364253","phase":"NA","title":"'Propolis Versus Chlorhexidine Gluconate on Wound Healing After Third Molar Surgery: a Randomized Controlled Trial'","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2021-01-05","conditions":"Third Molar Surgery, Post Operative Analgesia","enrollment":52},{"nctId":"NCT06396078","phase":"PHASE4","title":"Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2024-07-18","conditions":"Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth","enrollment":56},{"nctId":"NCT06229288","phase":"PHASE3","title":"Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit Ward","status":"RECRUITING","sponsor":"Nantes University Hospital","startDate":"2024-04-25","conditions":"Community-acquired Pneumonia","enrollment":326},{"nctId":"NCT06681246","phase":"NA","title":"The Role of Microbiome in Recurrent Obesity Before and After Antibiotic/Placebo Treatment","status":"RECRUITING","sponsor":"Weizmann Institute of Science","startDate":"2024-12-11","conditions":"Obesity, Weight Loss","enrollment":200},{"nctId":"NCT07030673","phase":"NA","title":"Early Discontinuation of Antibiotic Therapy in Elderly Patients Hospitalized for a Viral Infection","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2025-02-14","conditions":"Elderly, Antibiotics Overuse, Viral Infections","enrollment":256},{"nctId":"NCT02456974","phase":"","title":"Antibiotic Dosing in Pediatric Intensive Care","status":"RECRUITING","sponsor":"University Hospital, Ghent","startDate":"2012-05","conditions":"Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam","enrollment":640},{"nctId":"NCT06426836","phase":"NA","title":"Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)","status":"RECRUITING","sponsor":"University Hospital, Ghent","startDate":"2016-08-19","conditions":"Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam","enrollment":300},{"nctId":"NCT02783859","phase":"PHASE4","title":"Hospitalised Pneumonia With Extended Treatment (HOPE) Study","status":"COMPLETED","sponsor":"Menzies School of Health Research","startDate":"2016-06","conditions":"Pneumonia","enrollment":314},{"nctId":"NCT07335627","phase":"","title":"Clindamycin as Antimicrobial Treatment for Streptococcus Spp. PeRiprosthetic Infection","status":"RECRUITING","sponsor":"University Hospital, Strasbourg, France","startDate":"2025-02-21","conditions":"Streptococcus Infection","enrollment":260},{"nctId":"NCT04549311","phase":"PHASE3","title":"Perianal Abscess Recurrence and Fistula Formation: Antibiotics Following Incision and Drainage Trial","status":"COMPLETED","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2021-11-18","conditions":"Perianal Abscess, Perianal Fistula","enrollment":15},{"nctId":"NCT07015736","phase":"PHASE4","title":"Effects of Saccharomyces Boulardii CNCM I-745 on Antibiotic-Associated Perturbation in Children Treated for Acute Respiratory Infections (RESTORE Study)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eskisehir Osmangazi University","startDate":"2025-08-01","conditions":"Antibiotic Associated Diarrhea, Acute Otitis Media, ACUTE SINUSITIS","enrollment":100},{"nctId":"NCT05079620","phase":"PHASE4","title":"Early Antibiotics After Aspiration in ICU Patients","status":"TERMINATED","sponsor":"UConn Health","startDate":"2021-11-30","conditions":"Aspiration, Aspiration Pneumonia","enrollment":5},{"nctId":"NCT07296302","phase":"NA","title":"Antibiotic Prophylaxis Versus Placebo in Alveolar Bone Grafting: A Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Agnaldo Rocha de Souza Junior","startDate":"2026-02","conditions":"Alveolar Ridge Augmentation, Bone Grafting, Antibiotic Prophylaxis","enrollment":150},{"nctId":"NCT02281929","phase":"PHASE3","title":"Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2015-06-13","conditions":"Alcoholic Hepatitis, Alcoholic Liver Disease","enrollment":297},{"nctId":"NCT01388413","phase":"PHASE4","title":"Safety and Efficacy of a Weekly Oral Cyclic Antibiotic Programme in the Prevention of Urinary Tract Infection on Neurological Bladder","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2011-08","conditions":"Neurogenic Bladder, Urinary Tract Infection","enrollment":45},{"nctId":"NCT07183462","phase":"PHASE4","title":"Azithromycin and Ampicillin for Late PPROM","status":"RECRUITING","sponsor":"Sheba Medical Center","startDate":"2025-09-10","conditions":"Pregnancy Complications, Infectious, Premature Birth, Neonatal Diseases and Abnormalities","enrollment":311},{"nctId":"NCT07236944","phase":"PHASE4","title":"Pivmecillinam as Oral Step-Down Treatment for Escherichia Coli Febrile Urinary Tract Infection Versus Standard of Care","status":"RECRUITING","sponsor":"Uppsala University","startDate":"2025-12","conditions":"Febrile Urinary Tract Infection","enrollment":560},{"nctId":"NCT07104318","phase":"PHASE3","title":"Personalized vs Standard of Care Treatment for Helicobacter Pylori Eradication Among Veterans","status":"NOT_YET_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-04-01","conditions":"Helicobacter Pylori","enrollment":360},{"nctId":"NCT06294600","phase":"PHASE3","title":"Clarithromycin Treatment to Prevent Sepsis Progression in CAP (REACT)","status":"RECRUITING","sponsor":"Hellenic Institute for the Study of Sepsis","startDate":"2024-02-12","conditions":"Community-acquired Pneumonia","enrollment":330},{"nctId":"NCT02779179","phase":"NA","title":"Therapeutic Management of Periodontitis and Clinical Manifestations of Rheumatoid Arthritis","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2010-11","conditions":"Periodontitis, Rheumatoid Arthritis","enrollment":22},{"nctId":"NCT07275580","phase":"PHASE4","title":"Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases","status":"NOT_YET_RECRUITING","sponsor":"University of Sao Paulo General Hospital","startDate":"2026-01-10","conditions":"Autoimmune Rheumatic Diseases, Tooth Extraction, Infection Prevention","enrollment":352},{"nctId":"NCT07269171","phase":"NA","title":"The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery","status":"NOT_YET_RECRUITING","sponsor":"Saglik Bilimleri Universitesi","startDate":"2025-12-01","conditions":"Oral Health Care","enrollment":15},{"nctId":"NCT04350502","phase":"NA","title":"Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2019-07-18","conditions":"Pleural Infection, Empyema, Community-acquired Pneumonia","enrollment":11},{"nctId":"NCT05206500","phase":"PHASE4","title":"NextGen - Clinical Implication of Next Generation Sequencing","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2022-05-17","conditions":"Urinary Tract Infections","enrollment":100},{"nctId":"NCT06823154","phase":"PHASE1","title":"The Implementation and Impact of an Allergy De-Labeling Program in the Emergency Department","status":"ENROLLING_BY_INVITATION","sponsor":"The Hospital for Sick Children","startDate":"2023-11-27","conditions":"Allergy Amoxicillin, Beta-lactam Allergy Labels","enrollment":500},{"nctId":"NCT07234448","phase":"NA","title":"Evaluation of the Use of a Probiotic Containing Bifidobacterium Breve PRL2020 in Oral Drops in Preventing Side Effects From Amoxicillin or Amoxicillin/Clavulanic Acid Antibiotic Use","status":"NOT_YET_RECRUITING","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2025-12-01","conditions":"Antibiotic-associated Diarrhea","enrollment":1000},{"nctId":"NCT06126731","phase":"PHASE1, PHASE2","title":"Combination Study of Antibiotics With Enzalutamide (PROMIZE)","status":"RECRUITING","sponsor":"Institute of Cancer Research, United Kingdom","startDate":"2023-11-02","conditions":"Metastatic Castration-Resistant Prostate Cancer (mCRPC)","enrollment":39},{"nctId":"NCT05840588","phase":"NA","title":"Effect of Bifidobacterium Breve PRL2020 (an Amoxicillin-clavulanate-resistant Strain) on Gastrointestinal Symptoms and Gut Microbiota Composition in Children Treated With Amoxicillin or Amoxicillin/Clavulanate","status":"COMPLETED","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2023-11-06","conditions":"Bacterial Infections","enrollment":121},{"nctId":"NCT07242443","phase":"PHASE4","title":"Tegoprazan Plus Amoxicillin BID vs TID Regimens for H. Pylori Eradication（Frequency Adjusted Same-dose Therapy for H. Pylori）","status":"NOT_YET_RECRUITING","sponsor":"First People's Hospital of Hangzhou","startDate":"2025-11-20","conditions":"HELICOBACTER PYLORI INFECTIONS","enrollment":240},{"nctId":"NCT01543334","phase":"","title":"Antibiotic Concentrations Among Critically Ill Patients","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2012-03","conditions":"Administration of Antibiotics in Intensive Care Units","enrollment":98},{"nctId":"NCT07233733","phase":"NA","title":"A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects","status":"COMPLETED","sponsor":"Phạm Đình Thiên Khải","startDate":"2024-06-01","conditions":"Periodontal Diseases, Regeneration","enrollment":17},{"nctId":"NCT05846399","phase":"PHASE4","title":"CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)","status":"RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2023-09-07","conditions":"Cat Bite, Hand Injuries, Arm Injury","enrollment":72},{"nctId":"NCT07202091","phase":"PHASE2, PHASE3","title":"Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Immunoglobulin Stopping or Extension (Stop Ig)","status":"RECRUITING","sponsor":"Monash University","startDate":"2025-05-06","conditions":"Myeloma, Leukemia, Non Hodgkin's Lymphoma","enrollment":900},{"nctId":"NCT07202052","phase":"PHASE2, PHASE3","title":"Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT)","status":"RECRUITING","sponsor":"Monash University","startDate":"2025-05-06","conditions":"Myeloma, Non-Hodgkin's Lymphoma, Leukemia","enrollment":900},{"nctId":"NCT07104370","phase":"NA","title":"Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws","status":"RECRUITING","sponsor":"Semmelweis University","startDate":"2025-09-29","conditions":"Edentulous Alveolar Ridge, Edentulous Alveolar Ridge Atrophy","enrollment":30},{"nctId":"NCT05332444","phase":"PHASE4","title":"Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection","status":"RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2022-04-11","conditions":"Helicobacter Pylori Infection","enrollment":450},{"nctId":"NCT01015417","phase":"PHASE3","title":"Place of Antibiotics in the Postoperative Acute Lithiasic Cholecystitis","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2010-05","conditions":"Acute Lithiasic Cholecystitis Grade I or II, Symptoms Lasting for Less Than 5 Days, Required Cholecystectomy","enrollment":414},{"nctId":"NCT06443502","phase":"PHASE3","title":"A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis","status":"RECRUITING","sponsor":"Takeda","startDate":"2024-11-19","conditions":"Pouchitis","enrollment":30},{"nctId":"NCT06273891","phase":"PHASE3","title":"Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes","status":"RECRUITING","sponsor":"Inova Health Care Services","startDate":"2024-03-08","conditions":"Premature Rupture of Membrane","enrollment":140},{"nctId":"NCT05874544","phase":"PHASE4","title":"Rescue Therapy for Helicobacter Pylori Infection","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2023-05-16","conditions":"Helicobacter Pylori Infection","enrollment":360},{"nctId":"NCT02707042","phase":"PHASE1","title":"Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2017-03-22","conditions":"Normal Physiology, Healthy","enrollment":108},{"nctId":"NCT07077122","phase":"NA","title":"Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols","status":"RECRUITING","sponsor":"National and Kapodistrian University of Athens","startDate":"2025-08-25","conditions":"Periodontitis","enrollment":75},{"nctId":"NCT07150286","phase":"NA","title":"Helicobacter Pylori Eradication Therapy for Immune Thrombocytopenia (ITP) Patients in Iraq","status":"COMPLETED","sponsor":"Al-Mustansiriyah University","startDate":"2024-09-01","conditions":"Immune Thrombocytopenic Purpura, HELICOBACTER PYLORI INFECTIONS","enrollment":100},{"nctId":"NCT07148622","phase":"NA","title":"Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2024-10-01","conditions":"Preterm Premature Rupture of Membranes (PPROM), Prophylaxis, Perinatal Outcomes","enrollment":40},{"nctId":"NCT07146594","phase":"PHASE4","title":"Clinical Evaluation of a 14day Modified Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori in a High Clarithromycin and Metronidazole Resistance Area Regarding Patients With Peptic Ulcer and Non Ulcer Dyspepsia","status":"NOT_YET_RECRUITING","sponsor":"Athens Medical Center","startDate":"2025-08-20","conditions":"Helicobacter Pylori Gastritis, Helicobacter Eradication","enrollment":150},{"nctId":"NCT06451913","phase":"PHASE4","title":"Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))","status":"RECRUITING","sponsor":"Biocodex","startDate":"2025-07-16","conditions":"Erythema Migrans of Lyme Disease","enrollment":120},{"nctId":"NCT05977868","phase":"PHASE4","title":"Comparing Oral Versus Parenteral Antimicrobial Therapy","status":"TERMINATED","sponsor":"West Virginia University","startDate":"2023-08-04","conditions":"Endovascular Infection, Bone and Joint Infection, Skin and Soft Tissue Infection","enrollment":94},{"nctId":"NCT05464615","phase":"EARLY_PHASE1","title":"Geisinger Antibiotic Allergy Pilot Program: Assess and Address","status":"RECRUITING","sponsor":"Geisinger Clinic","startDate":"2024-03-04","conditions":"Penicillin Allergy","enrollment":100},{"nctId":"NCT03273296","phase":"PHASE4","title":"Effect of Antibiotics on Gut Microbiome and Plasma Metabolome","status":"COMPLETED","sponsor":"Finnish Institute for Health and Welfare","startDate":"2017-10-15","conditions":"Microbial Colonization","enrollment":39},{"nctId":"NCT07068607","phase":"PHASE4","title":"Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial","status":"RECRUITING","sponsor":"Yongquan Shi","startDate":"2025-04-01","conditions":"Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer","enrollment":400},{"nctId":"NCT06131021","phase":"PHASE3","title":"Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice","status":"RECRUITING","sponsor":"Rutgers, The State University of New Jersey","startDate":"2024-04-25","conditions":"Periodontitis, Periodontal Diseases, Periodontal Pocket","enrollment":150},{"nctId":"NCT06771492","phase":"PHASE3","title":"Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial","status":"RECRUITING","sponsor":"Bart Koes","startDate":"2025-04-02","conditions":"MSK Conditions, Chronic Low Back Pain (CLBP), Modic Changes","enrollment":204},{"nctId":"NCT06423898","phase":"PHASE4","title":"Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.","status":"RECRUITING","sponsor":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","startDate":"2024-10-09","conditions":"Endocarditis, Infective","enrollment":284},{"nctId":"NCT07082465","phase":"","title":"Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand","status":"NOT_YET_RECRUITING","sponsor":"University of Oxford","startDate":"2025-08-01","conditions":"Drug Resistance, Bacterial, Bacteremia","enrollment":108000},{"nctId":"NCT05608564","phase":"NA","title":"Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy","status":"COMPLETED","sponsor":"University of Belgrade","startDate":"2023-01-17","conditions":"Periodontitis","enrollment":38},{"nctId":"NCT04198129","phase":"PHASE1","title":"The Evaluation of Postoperative Antibiotics in Non-Infected Mandible Fractures","status":"TERMINATED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2020-10-01","conditions":"Jaw Fractures, Infection","enrollment":13},{"nctId":"NCT03479736","phase":"","title":"A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2017-11-20","conditions":"Retinal Detachment, Achilles Tendon, Aneurysm, Dissecting","enrollment":117911},{"nctId":"NCT03369717","phase":"PHASE4","title":"Use of Perioperative Antibiotics in Endoscopic Sinus Surgery","status":"TERMINATED","sponsor":"Montefiore Medical Center","startDate":"2018-08-01","conditions":"Chronic Sinus Infection","enrollment":24},{"nctId":"NCT06461429","phase":"NA","title":"PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol]","status":"NOT_YET_RECRUITING","sponsor":"University of Melbourne","startDate":"2025-11-01","conditions":"Preterm Birth","enrollment":100000},{"nctId":"NCT02570347","phase":"PHASE4","title":"Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite","status":"TERMINATED","sponsor":"Jawaharlal Institute of Postgraduate Medical Education & Research","startDate":"2016-05-03","conditions":"Snake Bites","enrollment":66},{"nctId":"NCT06166667","phase":"NA","title":"Effect of Fecal Capsule on Chronic Kidney Disease (CKD)","status":"COMPLETED","sponsor":"Shanxi Provincial People's Hospital","startDate":"2023-03-01","conditions":"Renal Insufficiency, Chronic","enrollment":20},{"nctId":"NCT06973889","phase":"PHASE2","title":"Evaluation of IgY Antibody Efficacy in Egg Yolk Against Helicobacter Pylori in Bacterial Elimination and Clinical Symptoms Improvement of Gastrointestinal Patients","status":"COMPLETED","sponsor":"Mashhad University of Medical Sciences","startDate":"2023-12-04","conditions":"HELICOBACTER PYLORI INFECTIONS, Gastrointestinal Disease","enrollment":60},{"nctId":"NCT03031210","phase":"PHASE2, PHASE3","title":"Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia.","status":"RECRUITING","sponsor":"St. Justine's Hospital","startDate":"2017-06-11","conditions":"Community-acquired Pneumonia","enrollment":1370},{"nctId":"NCT06197308","phase":"EARLY_PHASE1","title":"Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC","status":"RECRUITING","sponsor":"University of Minnesota","startDate":"2024-03-01","conditions":"Primary Sclerosing Cholangitis","enrollment":28},{"nctId":"NCT06921213","phase":"PHASE2","title":"Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis","status":"NOT_YET_RECRUITING","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2025-10-01","conditions":"Syphilis, Congenital","enrollment":90},{"nctId":"NCT06953271","phase":"PHASE4","title":"Methenamine Hippurate Following Intradetrusor OnabotulinumtoxinA Injection","status":"NOT_YET_RECRUITING","sponsor":"Women and Infants Hospital of Rhode Island","startDate":"2025-05-15","conditions":"Overactive Bladder (OAB), Urinary Tract Infection (Diagnosis)","enrollment":164},{"nctId":"NCT03897244","phase":"PHASE4","title":"Efficacies of HDDT With or Without Bismuth vs Amoxicillin-metronidazole BQT for First-line H Pylori Eradication","status":"COMPLETED","sponsor":"National Taiwan University Hospital","startDate":"2019-05-30","conditions":"Helicobacter Pylori Infection","enrollment":603},{"nctId":"NCT05345457","phase":"PHASE4","title":"Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age","status":"RECRUITING","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2023-01-13","conditions":"Pregnancy Preterm, Pregnancy Prom, PROM, Preterm (Pregnancy)","enrollment":88},{"nctId":"NCT06929702","phase":"PHASE4","title":"Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Ghent","startDate":"2025-04-22","conditions":"Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem","enrollment":58},{"nctId":"NCT04563325","phase":"PHASE4","title":"Oral-only Antibiotics for Bone and Joint Infections in Children","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2020-09-15","conditions":"Osteomyelitis, Septic Arthritis, Bone Infection","enrollment":180},{"nctId":"NCT06827496","phase":"","title":"Initial Oral Antibiotics for Bone and Joint Infections in Children","status":"RECRUITING","sponsor":"Rigshospitalet, Denmark","startDate":"2024-11-15","conditions":"Osteomyelitis Acute, Septic Arthritis, Bone Infection","enrollment":100},{"nctId":"NCT06917157","phase":"PHASE4","title":"Latency Antibiotics for Previable Rupture Of Membranes Trial","status":"NOT_YET_RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2025-05-01","conditions":"Preterm Prelabor Rupture of Membranes (PPROM)","enrollment":60},{"nctId":"NCT06906757","phase":"NA","title":"Preterm Rupture of Membranes Optimising Antibiotics Trial","status":"NOT_YET_RECRUITING","sponsor":"University of Melbourne","startDate":"2025-09","conditions":"PPROM, Preterm","enrollment":3900},{"nctId":"NCT06850714","phase":"NA","title":"Evaluation of Bifidobacterium Breve PRL2020 in Preventing Antibiotic-Associated Side Effects From Amoxicillin or Amoxicillin/Clavulanic Acid","status":"NOT_YET_RECRUITING","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2025-02-23","conditions":"Antibiotic Side Effect","enrollment":800},{"nctId":"NCT05934227","phase":"NA","title":"Amoxicillin Plus Metronidazole in Periodontal Maintenance","status":"COMPLETED","sponsor":"Federal University of Minas Gerais","startDate":"2023-07-01","conditions":"Periodontitis, Periodontal Pocket","enrollment":50},{"nctId":"NCT04414722","phase":"EARLY_PHASE1","title":"Mechanisms of Probiotics and Antibiotic-Associated Diarrhea","status":"COMPLETED","sponsor":"Georgetown University","startDate":"2021-01-01","conditions":"Antibiotic-associated Diarrhea","enrollment":118},{"nctId":"NCT04048304","phase":"NA","title":"Short Post-surgical Antibiotic Therapy in Spine Infections - a Prospective, Randomized, Unblinded, Non-inferiority Trial","status":"RECRUITING","sponsor":"Balgrist University Hospital","startDate":"2019-07-31","conditions":"Infection","enrollment":236},{"nctId":"NCT06811207","phase":"PHASE3","title":"Comparison of the Efficacies of Two Novel Dose Dual Therapies in the First-line Helicobacter Pylori Eradication","status":"UNKNOWN","sponsor":"Chang Gung Memorial Hospital","startDate":"2025-02-01","conditions":"HELICOBACTER PYLORI INFECTIONS","enrollment":300},{"nctId":"NCT05553743","phase":"","title":"Researchers At UC San Diego Are Learning About the Benefits of Human Milk and How It Influences Infant and Child Health","status":"RECRUITING","sponsor":"University of California, San Diego","startDate":"2014-03-27","conditions":"Breastfeeding, COVID-19 Infection, COVID-19 Vaccine","enrollment":5000},{"nctId":"NCT04140903","phase":"PHASE4","title":"Partial Oral Antibiotic Treatment for Bacterial Brain Abscess","status":"RECRUITING","sponsor":"Henrik Nielsen","startDate":"2020-11-06","conditions":"Brain Abscess, Cerebral Abscess","enrollment":400},{"nctId":"NCT06787027","phase":"NA","title":"Effect of Manual Massage Technique on Swelling, Pain and Mouth Opening After Bilateral Lower Third Molar Surgery","status":"COMPLETED","sponsor":"Izmir Katip Celebi University","startDate":"2018-03-01","conditions":"Impacted Third Molar Tooth, Swelling/ Edema, Pain","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":170,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Antibiotic (Amoxicillin)","genericName":"Antibiotic (Amoxicillin)","companyName":"Norwegian University of Science and Technology","companyId":"norwegian-university-of-science-and-technology","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and blocking peptidoglycan cross-linking. Used for Bacterial infections (respiratory tract, urinary tract, skin and soft tissue, otitis media, sinusitis), Helicobacter pylori eradication (as part of combination therapy).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}