{"id":"anti-hbv-antiviral-prophylaxis","safety":{"commonSideEffects":[{"rate":null,"effect":"Lactic acidosis"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL5917849","moleculeType":null,"molecularWeight":"445.93"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This prophylactic treatment is designed to prevent hepatitis B virus (HBV) infection or suppress viral replication in at-risk populations or those with chronic HBV. The specific mechanism likely involves nucleos(t)ide reverse transcriptase inhibitors or other antivirals that target HBV polymerase to reduce viral load and transmission risk.","oneSentence":"Anti-HBV antiviral prophylaxis prevents hepatitis B virus infection or reactivation by inhibiting viral replication through antiviral mechanisms.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:01:46.804Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hepatitis B virus prophylaxis"},{"name":"Prevention of HBV reactivation in at-risk populations"}]},"trialDetails":[{"nctId":"NCT03343431","phase":"PHASE3","title":"Antiviral Prophylaxis and Infant Vaccination to Prevent Perinatal Hepatitis B Infection","status":"ACTIVE_NOT_RECRUITING","sponsor":"Institut de Recherche pour le Developpement","startDate":"2018-08-02","conditions":"Hepatitis B, Pregnancy","enrollment":504},{"nctId":"NCT06676410","phase":"PHASE2","title":"Clinical Trial to Evaluate the Efficacy and Safety of Codivir® in Addition to Standard Antiretroviral Treatment for HIV Infection in Antiretroviral-naïve Participants","status":"RECRUITING","sponsor":"Code Pharma","startDate":"2023-07-20","conditions":"HIV, HIV Infection","enrollment":40},{"nctId":"NCT04199819","phase":"NA","title":"Detecting Occult HBV Infection in Liver Donors Positive for Antibody to Hepatitis B Core Antigen (Anti-HBc)","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2022-01-01","conditions":"Occult Hepatitis B, Liver Transplant; Complications","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":23,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["tenofovir disoproxil fumarate"],"phase":"phase_3","status":"active","brandName":"Anti-HBV antiviral prophylaxis","genericName":"Anti-HBV antiviral prophylaxis","companyName":"Institut de Recherche pour le Developpement","companyId":"institut-de-recherche-pour-le-developpement","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Anti-HBV antiviral prophylaxis prevents hepatitis B virus infection or reactivation by inhibiting viral replication through antiviral mechanisms. Used for Hepatitis B virus prophylaxis, Prevention of HBV reactivation in at-risk populations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}