{"id":"anti-drug-antibodies-dosage","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"When patients receive biologic therapeutics (monoclonal antibodies, recombinant proteins, etc.), their immune system may recognize the drug as foreign and generate antibodies against it. These anti-drug antibodies can neutralize the therapeutic agent, accelerate its elimination from circulation, or trigger immune complex formation, thereby diminishing clinical efficacy and potentially causing adverse immunological reactions.","oneSentence":"Anti-drug antibodies (ADAs) are immune responses that develop against therapeutic drugs, potentially reducing drug efficacy and increasing clearance.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:10:13.869Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Detection and monitoring of anti-drug antibodies in patients receiving biologic therapeutics"}]},"trialDetails":[{"nctId":"NCT01896999","phase":"PHASE1, PHASE2","title":"Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2014-03-07","conditions":"Recurrent Classic Hodgkin 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