{"id":"anti-caries-varnish","safety":{"commonSideEffects":[{"rate":null,"effect":"Gingivitis"}]},"_chembl":{"chemblId":"CHEMBL2108941","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The fluoride ions released by the varnish help to remineralize tooth enamel, making it more resistant to decay. This process also helps to reduce the risk of tooth sensitivity and gum recession.","oneSentence":"Anti-caries varnish works by releasing fluoride ions to strengthen tooth enamel and prevent acid attacks from plaque bacteria.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:09:50.410Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of dental caries in high-risk patients"}]},"trialDetails":[{"nctId":"NCT04947527","phase":"PHASE2","title":"Efficacy and Safety Evaluation of Anti-Caries Varnish","status":"COMPLETED","sponsor":"Advantage Silver Dental Arrest, LLC","startDate":"2022-06-04","conditions":"Dental Caries in Children","enrollment":274},{"nctId":"NCT03082196","phase":"PHASE2","title":"Efficacy Of A PVP-I Fluoride Varnish","status":"COMPLETED","sponsor":"Advantage Dental Services, LLC","startDate":"2017-03-30","conditions":"Dental Caries","enrollment":284},{"nctId":"NCT04183231","phase":"PHASE2","title":"Pharmacokinetics of Advantage Anti-Caries Varnish","status":"COMPLETED","sponsor":"Advantage Silver Dental Arrest, LLC","startDate":"2016-11-01","conditions":"Dental Caries","enrollment":16},{"nctId":"NCT02645617","phase":"PHASE1","title":"Safety Evaluation of Advantage Anti-Caries Varnish","status":"COMPLETED","sponsor":"Advantage Dental Services, LLC","startDate":"2016-03-30","conditions":"Dental Caries","enrollment":12},{"nctId":"NCT02341352","phase":"PHASE3","title":"Three Measures for the Prevention of Carious Lesions in Preschool Children","status":"UNKNOWN","sponsor":"Zhejiang University","startDate":"2013-04","conditions":"Dental Caries","enrollment":500}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":21,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Anti-caries varnish","genericName":"Anti-caries varnish","companyName":"Advantage Silver Dental Arrest, LLC","companyId":"advantage-silver-dental-arrest-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Anti-caries varnish works by releasing fluoride ions to strengthen tooth enamel and prevent acid attacks from plaque bacteria. Used for Prevention of dental caries in high-risk patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}