{"id":"antagon","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":{"chemblId":"CHEMBL505","moleculeType":"Small molecule","molecularWeight":"274.80"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Antagon binds competitively to GnRH receptors on pituitary gonadotroph cells, causing immediate and reversible suppression of gonadotropin secretion. This prevents the endogenous LH surge that would otherwise trigger premature ovulation during controlled ovarian hyperstimulation in fertility treatment cycles.","oneSentence":"Antagon is a gonadotropin-releasing hormone (GnRH) antagonist that rapidly suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to prevent premature ovulation during assisted reproductive technology.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:35.426Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (ART)"}]},"trialDetails":[{"nctId":"NCT00298025","phase":"PHASE4","title":"A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian Stimulation","status":"COMPLETED","sponsor":"EMD Serono","startDate":"2003-09","conditions":"Infertile Women Undergoing Assisted Reproductive Technology (ART)","enrollment":185},{"nctId":"NCT00826839","phase":"PHASE4","title":"Oral Microdose Lupron Versus Luteal Estradiol Trial in Poor Responder In Vitro Fertilization (IVF) Patients","status":"WITHDRAWN","sponsor":"Weill Medical College of Cornell University","startDate":"2009-01","conditions":"Infertility","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ganirelix acetate"],"phase":"marketed","status":"active","brandName":"Antagon ™","genericName":"Antagon ™","companyName":"EMD Serono","companyId":"emd-serono","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Antagon is a gonadotropin-releasing hormone (GnRH) antagonist that rapidly suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to prevent premature ovulation during assisted reproductive technology. Used for Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (ART).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}