{"id":"antabuse-disulfiram","safety":{"commonSideEffects":[{"rate":null,"effect":"Disulfiram-alcohol reaction (flushing, nausea, vomiting, chest pain, hypotension)"},{"rate":null,"effect":"Peripheral neuropathy"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Metallic taste"},{"rate":null,"effect":"Drowsiness"}]},"_chembl":{"chemblId":"CHEMBL964","moleculeType":"Small molecule","molecularWeight":"296.55"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Disulfiram irreversibly inhibits aldehyde dehydrogenase (ALDH), the enzyme responsible for metabolizing acetaldehyde, an intermediate in alcohol metabolism. When a patient taking disulfiram consumes alcohol, acetaldehyde accumulates to toxic levels, triggering an unpleasant disulfiram-alcohol reaction characterized by flushing, nausea, vomiting, chest pain, and hypotension. This aversive conditioning is intended to reinforce abstinence in alcohol use disorder treatment.","oneSentence":"Disulfiram inhibits the enzyme aldehyde dehydrogenase, causing toxic acetaldehyde accumulation when alcohol is consumed, producing an aversive reaction that discourages drinking.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:24.608Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Alcohol use disorder (maintenance of abstinence)"}]},"trialDetails":[{"nctId":"NCT05210374","phase":"PHASE1","title":"Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas","status":"RECRUITING","sponsor":"Case Comprehensive Cancer Center","startDate":"2023-03-09","conditions":"Relapsed Sarcomas","enrollment":24},{"nctId":"NCT07477457","phase":"PHASE2","title":"A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With 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Used for Alcohol use disorder (maintenance of abstinence).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}