{"id":"anoro-ellipta","brandName":"Anoro® Ellipta®","genericName":"Anoro® Ellipta®","companyId":"astrazeneca","companyName":"AstraZeneca","phase":"marketed","status":"active","modality":"Small molecule","aliases":["Anoro® - Umeclidinium/Vilanterol","Ellipta® - Device","umeclidinium + vilanterol"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Anoro® Ellipta® is a fixed-dose combination inhaler containing indacaterol maleate and glycopyrronium bromide, indicated for COPD. It has completed several clinical trials, demonstrating efficacy and safety. Despite no FDA label, it remains a key treatment option in COPD management.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug contains umeclidinium (a long-acting muscarinic antagonist) and vilanterol (a long-acting beta-2 agonist). These two bronchodilators work synergistically through different pathways: the beta-2 agonist increases cAMP to relax smooth muscle, while the muscarinic antagonist blocks acetylcholine-mediated bronchoconstriction. Together they provide sustained bronchodilation and improved lung function in COPD patients.","oneSentence":"Anoro Ellipta combines a long-acting beta-2 agonist and a long-acting muscarinic antagonist to relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Muscle cramps"},{"rate":null,"effect":"Nervousness"}]},"trials":[],"indications":{"approved":[{"name":"Chronic obstructive pulmonary disease (COPD) maintenance treatment"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}