{"id":"anisotropine-methylbromide","rwe":[],"tags":[{"label":"octatropine methylbromide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Muscarinic acetylcholine receptor M1","category":"target"},{"label":"CHRM1","category":"gene"},{"label":"CHRM3","category":"gene"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Mature","category":"status"},{"label":"Gastric ulcer","category":"indication"},{"label":"Peptic ulcer","category":"indication"},{"label":"Endo Pharms","category":"company"},{"label":"Approved 1960s","category":"decade"},{"label":"Cholinergic Agents","category":"pharmacology"},{"label":"Cholinergic Antagonists","category":"pharmacology"},{"label":"Muscarinic Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"marketed","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"company":"Endo","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=ANISOTROPINE METHYLBROMIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:45:31.302817+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:45:36.681437+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ANISOTROPINE METHYLBROMIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:45:37.032429+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Muscarinic acetylcholine receptor M1 antagonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:45:38.206375+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1578/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:45:37.861117+00:00"}},"allNames":"valpin","offLabel":[],"synonyms":["octatropine methylbromide","anisotropine methylbromide","anisotropine methobromide","anisotropine methyl bromide","valpin"],"timeline":[{"date":"1962-11-23","type":"positive","source":"DrugCentral","milestone":"FDA approval (Endo Pharms)"}],"aiSummary":"Valpin (Anisotropine Methylbromide) is a small molecule drug developed by ENDO PHARMS, targeting the muscarinic acetylcholine receptor M1. It is classified as an octatropine methylbromide and was approved by the FDA in 1962 for the treatment of gastric and peptic ulcers. As an off-patent medication, it is available as a generic option. Key safety considerations include its relatively low bioavailability of 18%. Valpin is no longer under patent protection, allowing multiple generic manufacturers to produce the medication.","brandName":"Valpin","ecosystem":[{"indication":"Gastric ulcer","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"cimetidine","slug":"cimetidine","company":""},{"name":"famotidine","slug":"famotidine","company":"Valeant Pharms North"},{"name":"lansoprazole","slug":"lansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":null},{"indication":"Peptic ulcer","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"chlordiazepoxide","slug":"chlordiazepoxide","company":"Valeant Pharm Intl"},{"name":"dexlansoprazole","slug":"dexlansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":64000000}],"mechanism":{"target":"Muscarinic acetylcholine receptor M1","novelty":"Follow-on","targets":[{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"}],"modality":"Small Molecule","drugClass":"octatropine methylbromide","explanation":"","oneSentence":"","technicalDetail":"Valpin exerts its effects by competitively antagonizing the muscarinic acetylcholine receptor M1, which is involved in the regulation of gastric acid secretion. By blocking this receptor, Valpin reduces the parasympathetic stimulation of gastric acid secretion, leading to a decrease in gastric acid production and a subsequent reduction in ulcer symptoms."},"commercial":{"launchDate":"1962","_launchSource":"DrugCentral (FDA 1962-11-23, ENDO PHARMS)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/223","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ANISOTROPINE METHYLBROMIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T02:42:57.399906","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:45:39.493942+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"acetylcholine","drugSlug":"acetylcholine","fdaApproval":"1973-10-09","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"aclidinium bromide","drugSlug":"aclidinium-bromide","fdaApproval":"2012-07-23","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amoxapine","drugSlug":"amoxapine","fdaApproval":"1980-09-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"atropine","drugSlug":"atropine","fdaApproval":"1960-09-15","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"azelastine","drugSlug":"azelastine","fdaApproval":"1996-11-01","patentExpiry":"Jun 4, 2028","patentStatus":"Patent protected","relationship":"same-target"}],"genericName":"anisotropine methylbromide","indications":{"approved":[{"name":"Gastric ulcer","source":"DrugCentral","snomedId":397825006,"regulator":"FDA"},{"name":"Peptic ulcer","source":"DrugCentral","snomedId":13200003,"regulator":"FDA","globalPrevalence":64000000,"prevalenceMethod":"ai-extracted","prevalenceSource":"Aliment Pharmacol Ther, 2009 (PMID:19220208)"}],"offLabel":[{"name":"Irritable bowel syndrome","source":"DrugCentral","drugName":"ANISOTROPINE METHYLBROMIDE","evidenceCount":0,"evidenceLevel":"emerging"}],"pipeline":[]},"drugCategory":"mature","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"acetylcholine","brandName":"acetylcholine","genericName":"acetylcholine","approvalYear":"1973","relationship":"same-target"},{"drugId":"aclidinium-bromide","brandName":"aclidinium bromide","genericName":"aclidinium 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Pharms","relationship":"Original Developer"}],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"18%"},"publicationCount":18,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"originalDeveloper":"Endo Pharms","recentPublications":[],"companionDiagnostics":[],"genericManufacturers":1,"_genericFilersChecked":true,"genericManufacturerList":["Watson Labs"],"status":"approved","companyName":"Endo","companyId":"endo","modality":"Small molecule","firstApprovalDate":"1962","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health 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