{"id":"anisindione","rwe":[],"tags":[{"label":"anisindione","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Vitamin K-dependent gamma-carboxylase","category":"target"},{"label":"GGCX","category":"gene"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Schering","category":"company"},{"label":"Approved 1950s","category":"decade"}],"phase":"marketed","safety":{"drugInteractions":[{"url":"/drug/vitamin-e","drug":"Vitamin E","action":"Monitor closely","effect":"May interact with Vitamin E","source":"DrugCentral","drugSlug":"vitamin-e"},{"url":"/drug/acetylsalicylic-acid","drug":"acetylsalicylic acid","action":"Monitor closely","effect":"May interact with Aspirin","source":"DrugCentral","drugSlug":"acetylsalicylic-acid"},{"url":"/drug/bismuth-subsalicylate","drug":"bismuth subsalicylate","action":"Avoid combination","effect":"May interact with Bismuth Subsalicylate","source":"DrugCentral","drugSlug":"bismuth-subsalicylate"},{"url":"/drug/carbamazepine","drug":"carbamazepine","action":"Avoid combination","effect":"May interact with Carbamazepine","source":"DrugCentral","drugSlug":"carbamazepine"},{"url":"/drug/cholestyramine","drug":"cholestyramine","action":"Monitor closely","effect":"May interact with Cholestyramine","source":"DrugCentral","drugSlug":"cholestyramine"},{"url":"/drug/choline-salicylate","drug":"choline salicylate","action":"Avoid combination","effect":"May interact with Choline Salicylate","source":"DrugCentral","drugSlug":"choline-salicylate"},{"url":"/drug/cimetidine","drug":"cimetidine","action":"Avoid combination","effect":"May interact with Cimetidine","source":"DrugCentral","drugSlug":"cimetidine"},{"url":"/drug/clofibrate","drug":"clofibrate","action":"Avoid combination","effect":"May interact with Clofibrate","source":"DrugCentral","drugSlug":"clofibrate"},{"url":"/drug/danazol","drug":"danazol","action":"Avoid combination","effect":"May interact with Danazol","source":"DrugCentral","drugSlug":"danazol"},{"url":"/drug/diclofenac","drug":"diclofenac","action":"Monitor closely","effect":"May interact with Diclofenac","source":"DrugCentral","drugSlug":"diclofenac"},{"url":"/drug/diflunisal","drug":"diflunisal","action":"Monitor closely","effect":"May interact with Diflunisal","source":"DrugCentral","drugSlug":"diflunisal"},{"url":"/drug/disulfiram","drug":"disulfiram","action":"Avoid combination","effect":"May interact with Disulfiram","source":"DrugCentral","drugSlug":"disulfiram"},{"url":"/drug/erythromycin","drug":"erythromycin","action":"Monitor closely","effect":"May interact with Erythromycin","source":"DrugCentral","drugSlug":"erythromycin"},{"url":"/drug/etodolac","drug":"etodolac","action":"Monitor closely","effect":"May interact with Etodolac","source":"DrugCentral","drugSlug":"etodolac"},{"url":"/drug/fenoprofen","drug":"fenoprofen","action":"Monitor closely","effect":"May interact with Fenoprofen","source":"DrugCentral","drugSlug":"fenoprofen"},{"url":"/drug/fluconazole","drug":"fluconazole","action":"Avoid combination","effect":"May interact with Fluconazole","source":"DrugCentral","drugSlug":"fluconazole"},{"url":"/drug/flurbiprofen","drug":"flurbiprofen","action":"Monitor closely","effect":"May interact with Flurbiprofen","source":"DrugCentral","drugSlug":"flurbiprofen"},{"url":"/drug/fosphenytoin","drug":"fosphenytoin","action":"Monitor closely","effect":"May interact with Fosphenytoin Sodium","source":"DrugCentral","drugSlug":"fosphenytoin"},{"url":"/drug/ibuprofen","drug":"ibuprofen","action":"Monitor closely","effect":"May interact with Ibuprofen","source":"DrugCentral","drugSlug":"ibuprofen"},{"url":"/drug/indomethacin","drug":"indomethacin","action":"Monitor closely","effect":"May interact with Indomethacin","source":"DrugCentral","drugSlug":"indomethacin"}],"commonSideEffects":[]},"trials":[],"aliases":[],"company":"Merck & Co.","patents":[],"pricing":[],"allNames":"andion","offLabel":[],"synonyms":["anisindione","andion","miradon","unidone"],"timeline":[{"date":"1957-04-05","type":"positive","source":"DrugCentral","milestone":"FDA approval (Schering)"}],"aiSummary":"Andion (ANISINDIONE) is a small molecule drug developed by SCHERING that targets Vitamin K-dependent gamma-carboxylase. It is an anisindione class medication, approved by the FDA in 1957 for certain indications. As an off-patent medication, there are no active Orange Book patents, and it is not currently manufactured by any generic manufacturers. Andion is used to treat certain conditions, but its exact indications and commercial status require further research. Key safety considerations are not well-documented due to the lack of available information.","brandName":"Andion","ecosystem":[],"mechanism":{"target":"Vitamin K-dependent gamma-carboxylase, Arachidonate 5-lipoxygenase","targets":[{"gene":"GGCX","source":"DrugCentral","target":"Vitamin K-dependent gamma-carboxylase","protein":"Vitamin K-dependent gamma-carboxylase"}],"modality":"Small Molecule","drugClass":"anisindione","explanation":"Think of Vitamin K-dependent gamma-carboxylase like a key that helps blood clotting proteins work properly. Andion blocks this key, preventing blood clots from forming. This can be helpful in certain medical conditions, but it also means that people taking Andion may be at risk of bleeding more easily.","oneSentence":"Andion works by inhibiting Vitamin K-dependent gamma-carboxylase, an enzyme necessary for blood clotting.","technicalDetail":"Andion (ANISINDIONE) is a competitive inhibitor of Vitamin K-dependent gamma-carboxylase, specifically targeting the enzyme's active site to prevent the gamma-carboxylation of vitamin K-dependent clotting factors."},"commercial":{"launchDate":"1957","_launchSource":"DrugCentral (FDA 1957-04-05, SCHERING)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/222","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ANISINDIONE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T08:48:02.460530","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"anisindione","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"_patentsChecked":true,"crossReferences":{"NUI":"N0000147108","MMSL":"1255","NDDF":"002091","UNII":"S747T1ERAJ","VUID":"4018805","CHEBI":"CHEBI:133809","VANDF":"4018805","INN_ID":"854","RXNORM":"17941","UMLSCUI":"C0051919","ChEMBL_ID":"CHEMBL712","KEGG_DRUG":"D07457","DRUGBANK_ID":"DB01125","PUBCHEM_CID":"2197","SNOMEDCT_US":"38122009","IUPHAR_LIGAND_ID":"6960","MESH_SUPPLEMENTAL_RECORD_UI":"C010679"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"1957-","companyName":"Schering","relationship":"Original Developer"}],"publicationCount":0,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"originalDeveloper":"Schering","recentPublications":[],"companionDiagnostics":[],"genericManufacturers":0,"_genericFilersChecked":true,"genericManufacturerList":[],"status":"approved","companyName":"Merck & Co.","companyId":"merck","modality":"Small molecule","firstApprovalDate":"1957","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"verificationStatus":"enriching","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}