{"id":"anhydrous-amiloride-hydrochloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Muscle weakness"}]},"_chembl":{"chemblId":"CHEMBL1398126","moleculeType":"Small molecule","molecularWeight":"302.12"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amiloride acts as an epithelial sodium channel (ENaC) inhibitor in the distal tubule and collecting duct of the kidney. By blocking sodium reabsorption, it promotes natriuresis and diuresis while preventing potassium loss, making it useful in conditions requiring fluid removal without hypokalemia. It is often used in combination with loop or thiazide diuretics to counteract their potassium-wasting effects.","oneSentence":"Amiloride is a potassium-sparing diuretic that blocks sodium reabsorption in the collecting duct of the nephron, thereby increasing sodium and water excretion while retaining potassium.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:27:24.648Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema associated with congestive heart failure"},{"name":"Hypertension"},{"name":"Hypokalemia prevention in patients on loop or thiazide diuretics"}]},"trialDetails":[{"nctId":"NCT05044611","phase":"PHASE4","title":"AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium","status":"ACTIVE_NOT_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2023-01-11","conditions":"Bipolar Disorder","enrollment":148}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Anhydrous Amiloride Hydrochloride","genericName":"Anhydrous Amiloride Hydrochloride","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amiloride is a potassium-sparing diuretic that blocks sodium reabsorption in the collecting duct of the nephron, thereby increasing sodium and water excretion while retaining potassium. Used for Edema associated with congestive heart failure, Hypertension, Hypokalemia prevention in patients on loop or thiazide diuretics.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}