{"id":"angiotensinamide","rwe":[],"tags":[{"label":"angiotensinamide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01CX06","category":"atc"},{"label":"Active","category":"status"},{"label":"Low blood pressure","category":"indication"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Vasoconstrictor Agents","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:34:10.136784","allNames":["angiotensinamide"],"offLabel":[],"synonyms":["angiotensinamide"],"timeline":[],"ecosystem":[{"indication":"Low blood pressure","otherDrugs":[{"name":"dopamine","slug":"dopamine","company":""},{"name":"epinephrine","slug":"epinephrine","company":""},{"name":"mephentermine","slug":"mephentermine","company":"Baxter Hlthcare Corp"},{"name":"metaraminol","slug":"metaraminol","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"angiotensinamide","explanation":"Think of the renin-angiotensin system like a feedback loop that helps regulate blood pressure. When blood pressure drops, the system kicks in to increase it. Angiotensinamide is thought to play a role in this process, but the exact details are not well understood.","oneSentence":"Angiotensinamide works by increasing blood pressure through a complex interaction with the renin-angiotensin system.","technicalDetail":"Angiotensinamide is believed to interact with the angiotensin II receptor, potentially increasing the levels of angiotensin II, a potent vasoconstrictor that helps raise blood pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4338","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=angiotensinamide","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=angiotensinamide","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:47:54.411730","biosimilars":[],"competitors":[{"drugName":"angiotensin II","drugSlug":"angiotensin-ii","fdaApproval":"2017-12-21","patentExpiry":"Nov 20, 2030","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"angiotensinamide","indications":{"approved":[{"name":"Low blood pressure","source":"DrugCentral","snomedId":45007003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(17)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"angiotensin-ii","brandName":"angiotensin II","genericName":"angiotensin II","approvalYear":"2017","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04991961","phase":"","title":"Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism","status":"COMPLETED","sponsor":"Chongqing Medical University","startDate":"2020-09-15","conditions":["Hypertension","Primary Aldosteronism"],"enrollment":341,"completionDate":"2024-10-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"7WAL1X78KV","INN_ID":"1057","UMLSCUI":"C0003001","ChEMBL_ID":"CHEMBL409803","DRUGBANK_ID":"DB13517","PUBCHEM_CID":"10351092","SECONDARY_CAS_RN":"53-73-6","MESH_DESCRIPTOR_UI":"D000802"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":17,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"C01CX06","allCodes":["C01CX06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2022","pmid":"34370631","title":"Quantitative structure-activity relationships, molecular docking and molecular dynamics simulations reveal drug repurposing candidates as potent SARS-CoV-2 main protease inhibitors.","journal":"Journal of biomolecular structure & dynamics"},{"date":"2003 Jul","pmid":"12843234","title":"Simple and accurate assessment of forward cardiac output by use of 1-(11)C-acetate PET verified in a pig model.","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine"},{"date":"1994 Apr","pmid":"8179137","title":"Angiotensinamide in the treatment of probable anaphylaxis to succinylated gelatin (Gelofusine).","journal":"Anaesthesia"},{"date":"1990 Sep-Oct","pmid":"2098755","title":"Synthesis of two new angiotensin II analogs.","journal":"Polish journal of pharmacology and pharmacy"},{"date":"1989 Nov-Dec","pmid":"2485905","title":"Effects of some new angiotensin II analogs on the reactivity of small arterioles in the mesentery of rat intestine.","journal":"Polish journal of pharmacology and pharmacy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"angiotensinamide","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Angiotensinamide is a protein modality that is a derivative of angiotensin II, a potent vasoconstrictor. It is being studied in clinical trials for its potential effects on hypertension and primary aldosteronism, particularly in the context of withdrawing antihypertensive medications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}