{"id":"anethole-trithione","rwe":[{"pmid":"40838212","year":"2025","title":"Iron single atom enzyme-mediated hydrogen sulfide delivery amplifies reactive oxygen species cascade to induce ferroptosis susceptibility.","finding":"","journal":"Materials today. Bio","studyType":"Clinical Study"},{"pmid":"40586691","year":"2025","title":"Activatable and Renal Metabolizable NIR-II Emissive Au Nanoprobe for Real-Time Monitoring of Kidney GSH.","finding":"","journal":"Nano letters","studyType":"Clinical Study"},{"pmid":"40580640","year":"2025","title":"Design, synthesis, and biological evaluation of a dual-action agent targeting bromodomain and extraterminal domain and H(2)S release for the treatment of hepatic and pulmonary injury.","finding":"","journal":"European journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"40365715","year":"2025","title":"Hydrogen Sulfide Modulates Microglial Polarization and Remodels the Injury Microenvironment to Promote Functional Recovery After Spinal Cord Injury.","finding":"","journal":"CNS neuroscience & therapeutics","studyType":"Clinical Study"},{"pmid":"40054324","year":"2025","title":"Anethole trithione mitigates LPS/D-Gal-induced acute liver injury by suppressing ROS production and NF-κB activity.","finding":"","journal":"International immunopharmacology","studyType":"Clinical Study"}],"tags":[{"label":"anethole trithione","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A16AX02","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:32:54.468903","allNames":"sulfogal","offLabel":[],"synonyms":["anethole trithione","anethole dithiolthione","sulfarlem","sulfogal","sulfralem","tiopropen","trithioanethole"],"timeline":[],"brandName":"Sulfogal","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"anethole trithione","explanation":"Imagine your body's cells are like locks, and Sulfogal is a key that fits into one of those locks. When it binds to the lock, it can affect how the cell works, but we don't know exactly how it does that yet. More research is needed to understand how Sulfogal interacts with cells and what effects it has on the body.","oneSentence":"Sulfogal works by interacting with a specific biological target, although its exact mechanism of action is currently unknown.","technicalDetail":"Sulfogal's mechanism of action is currently unknown, and further research is needed to determine its pharmacological properties and potential therapeutic applications."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/218","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=anethole trithione","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:44:00.072754","biosimilars":[],"competitors":[{"drugName":"thioctic acid","drugSlug":"thioctic-acid","fdaApproval":"","relationship":"same-class"},{"drugName":"phenylbutanoic acid","drugSlug":"phenylbutanoic-acid","fdaApproval":"1996-04-30","relationship":"same-class"},{"drugName":"nitisinone","drugSlug":"nitisinone","fdaApproval":"2002-01-18","patentExpiry":"Jan 5, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"zinc acetate","drugSlug":"zinc-acetate","fdaApproval":"1980-02-22","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"miglustat","drugSlug":"miglustat","fdaApproval":"2003-07-31","patentExpiry":"Sep 30, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sapropterin","drugSlug":"sapropterin","fdaApproval":"2007-12-13","patentExpiry":"Nov 1, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"teduglutide","drugSlug":"teduglutide","fdaApproval":"2012-12-21","patentExpiry":"May 1, 2026","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"glycerol phenylbutyrate","drugSlug":"glycerol-phenylbutyrate","fdaApproval":"2013-02-01","patentExpiry":"Sep 22, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"eliglustat","drugSlug":"eliglustat","fdaApproval":"2014-08-19","patentExpiry":"Nov 24, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sodium benzoate","drugSlug":"sodium-benzoate","fdaApproval":"1987-12-23","relationship":"same-class"},{"drugName":"trientine","drugSlug":"trientine","fdaApproval":"1985-11-08","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"uridine triacetate","drugSlug":"uridine-triacetate","fdaApproval":"2015-09-04","patentExpiry":"Aug 17, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"migalastat","drugSlug":"migalastat","fdaApproval":"2018-08-08","patentExpiry":"Oct 20, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"givosiran","drugSlug":"givosiran","fdaApproval":"2019-11-20","patentExpiry":"Oct 3, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"triheptanoin","drugSlug":"triheptanoin","fdaApproval":"2020-06-30","patentExpiry":"Nov 14, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"lumasiran","drugSlug":"lumasiran","fdaApproval":"2020-11-23","patentExpiry":"Oct 9, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fosdenopterin","drugSlug":"fosdenopterin","fdaApproval":"2021-02-26","patentExpiry":"Apr 9, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"lonafarnib","drugSlug":"lonafarnib","fdaApproval":"2020-11-20","patentExpiry":"Jul 26, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"phenylacetic acid","drugSlug":"phenylacetic-acid","fdaApproval":"1987-12-23","relationship":"same-class"}],"genericName":"anethole trithione","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(36)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"thioctic-acid","brandName":"thioctic acid","genericName":"thioctic acid","approvalYear":"","relationship":"same-class"},{"drugId":"phenylbutanoic-acid","brandName":"phenylbutanoic acid","genericName":"phenylbutanoic acid","approvalYear":"1996","relationship":"same-class"},{"drugId":"nitisinone","brandName":"nitisinone","genericName":"nitisinone","approvalYear":"2002","relationship":"same-class"},{"drugId":"zinc-acetate","brandName":"zinc acetate","genericName":"zinc acetate","approvalYear":"1980","relationship":"same-class"},{"drugId":"miglustat","brandName":"miglustat","genericName":"miglustat","approvalYear":"2003","relationship":"same-class"},{"drugId":"sapropterin","brandName":"sapropterin","genericName":"sapropterin","approvalYear":"2007","relationship":"same-class"},{"drugId":"teduglutide","brandName":"teduglutide","genericName":"teduglutide","approvalYear":"2012","relationship":"same-class"},{"drugId":"glycerol-phenylbutyrate","brandName":"glycerol phenylbutyrate","genericName":"glycerol phenylbutyrate","approvalYear":"2013","relationship":"same-class"},{"drugId":"eliglustat","brandName":"eliglustat","genericName":"eliglustat","approvalYear":"2014","relationship":"same-class"},{"drugId":"sodium-benzoate","brandName":"sodium benzoate","genericName":"sodium benzoate","approvalYear":"1987","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166632","NDDF":"003828","UNII":"QUY32964DJ","CHEBI":"CHEBI:31221","RXNORM":"820","UMLSCUI":"C0002937","ChEMBL_ID":"CHEMBL178862","DRUGBANK_ID":"DB13853","PUBCHEM_CID":"2194","SNOMEDCT_US":"703112006","MESH_DESCRIPTOR_UI":"D000781"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":36,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"A16AX02","allCodes":["A16AX02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Oct","pmid":"40838212","title":"Iron single atom enzyme-mediated hydrogen sulfide delivery amplifies reactive oxygen species cascade to induce ferroptosis susceptibility.","journal":"Materials today. Bio"},{"date":"2025 Jul 16","pmid":"40586691","title":"Activatable and Renal Metabolizable NIR-II Emissive Au Nanoprobe for Real-Time Monitoring of Kidney GSH.","journal":"Nano letters"},{"date":"2025 Oct 15","pmid":"40580640","title":"Design, synthesis, and biological evaluation of a dual-action agent targeting bromodomain and extraterminal domain and H(2)S release for the treatment of hepatic and pulmonary injury.","journal":"European journal of medicinal chemistry"},{"date":"2025 May","pmid":"40365715","title":"Hydrogen Sulfide Modulates Microglial Polarization and Remodels the Injury Microenvironment to Promote Functional Recovery After Spinal Cord Injury.","journal":"CNS neuroscience & therapeutics"},{"date":"2025 Apr 16","pmid":"40054324","title":"Anethole trithione mitigates LPS/D-Gal-induced acute liver injury by suppressing ROS production and NF-κB activity.","journal":"International immunopharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Sulfogal, also known as anethole trithione, is a small molecule drug of the anethole trithione class. Its mechanism of action and target are currently unknown. Sulfogal's commercial status and approved indications are also unclear. Further research is needed to determine its efficacy and safety profile. As a result, it is not possible to provide a comprehensive summary of its key safety considerations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}