{"id":"anesthetics-local","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reactions (rare with ester anesthetics)"},{"rate":null,"effect":"Systemic toxicity from overdose or intravascular injection"},{"rate":null,"effect":"Methemoglobinemia (with benzocaine)"},{"rate":null,"effect":"Transient neurological symptoms"}]},"_chembl":{"chemblId":"CHEMBL46058","moleculeType":"Small molecule","molecularWeight":"64.52"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Local anesthetics reversibly inhibit sodium influx through voltage-gated sodium channels in nerve fibers, which prevents depolarization and transmission of pain signals. This effect is localized to the area of administration, allowing for regional anesthesia without systemic effects. Different local anesthetics vary in potency, onset time, and duration based on their chemical structure and lipophilicity.","oneSentence":"Local anesthetics block sodium channels in nerve cell membranes, preventing the generation and propagation of action potentials to produce localized numbness and pain relief.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:49.032Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical and dental procedures"},{"name":"Pain relief in minor medical procedures and wound management"}]},"trialDetails":[{"nctId":"NCT07497009","phase":"NA","title":"Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial.","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-12-23","conditions":"Neurocognitive Function of Elderly Patients Post Operation","enrollment":30},{"nctId":"NCT07496632","phase":"NA","title":"Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients\"","status":"NOT_YET_RECRUITING","sponsor":"Bangladesh Medical University","startDate":"2026-04","conditions":"Scalp Block","enrollment":72},{"nctId":"NCT06807164","phase":"PHASE2","title":"Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome","status":"RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2026-03-31","conditions":"Post-Mastectomy Neuropathic Pain Syndrome","enrollment":123},{"nctId":"NCT07494383","phase":"NA","title":"Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial","status":"COMPLETED","sponsor":"ISSSTE Hospital Regional \"Gral. 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A Randomized Controlled Double Blinded Study.","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-01-01","conditions":"ESPB With Dexmetomidine May Provide Analgesia","enrollment":78},{"nctId":"NCT07457450","phase":"NA","title":"Intraosseous Anesthesia in MIH-Affected Teeth","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Zagreb","startDate":"2023-10-01","conditions":"Molar Incisor Hypomineralisation","enrollment":50},{"nctId":"NCT05044468","phase":"PHASE2","title":"EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2021-03-23","conditions":"Malignant Pleural Neoplasm","enrollment":80},{"nctId":"NCT07335250","phase":"NA","title":"Intertransverse Process Block for Postoperative Analgesia After Thoracotomy and Lobectomy","status":"RECRUITING","sponsor":"Konya City 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