{"id":"anesthetic-topical-adhesive-synera","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema at application site"},{"rate":null,"effect":"Edema at application site"},{"rate":null,"effect":"Blanching of skin"},{"rate":null,"effect":"Mild burning or irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Synera combines two local anesthetics—lidocaine and tetracaine—in a eutectic mixture formulation applied as a patch. The patch uses heat activation to enhance percutaneous penetration of these anesthetics into the dermis and subcutaneous tissue, blocking sodium channels in nerve fibers to produce local anesthesia without systemic absorption.","oneSentence":"Synera is a topical anesthetic patch that delivers lidocaine and tetracaine through the skin to numb the area before minor procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:32.671Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia for minor dermatological procedures (e.g., venipuncture, IV catheter insertion, laser procedures)"},{"name":"Superficial skin procedures requiring local anesthesia"}]},"trialDetails":[{"nctId":"NCT01834586","phase":"PHASE4","title":"Anesthetic Topical Adhesive (Synera™) to Reduce Injection Pain With Subcutaneous Multiple Sclerosis Medications","status":"COMPLETED","sponsor":"Brown, Theodore R., M.D., MPH","startDate":"2013-03","conditions":"Multiple Sclerosis","enrollment":30},{"nctId":"NCT01544283","phase":"PHASE2","title":"Pain Patch Versus Injections in the Treatment of Pain Associated With Shoulder Impingement Syndrome","status":"UNKNOWN","sponsor":"Injury Care Medical Center","startDate":"2012-03","conditions":"Shoulder Pain","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Synera"],"phase":"marketed","status":"active","brandName":"Anesthetic Topical Adhesive Synera","genericName":"Anesthetic Topical Adhesive Synera","companyName":"Brown, Theodore R., M.D., MPH","companyId":"brown-theodore-r-m-d-mph","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Synera is a topical anesthetic patch that delivers lidocaine and tetracaine through the skin to numb the area before minor procedures. Used for Topical anesthesia for minor dermatological procedures (e.g., venipuncture, IV catheter insertion, laser procedures), Superficial skin procedures requiring local anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}