{"id":"anesthetic-blockades-with-bupivacaine","safety":{"commonSideEffects":[{"rate":"null","effect":"Central nervous system toxicity"},{"rate":"null","effect":"Cardiovascular toxicity"},{"rate":"null","effect":"Nerve damage"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This blockade of sodium channels results in a loss of motor and sensory function in the affected area, providing effective pain relief. Bupivacaine's mechanism of action is reversible, and its effects can be reversed with the administration of a local anesthetic reversal agent.","oneSentence":"Bupivacaine works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:09:30.754Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management"},{"name":"Pain management during labor and delivery"}]},"trialDetails":[{"nctId":"NCT03838120","phase":"PHASE4","title":"Determination of Minimum Effective Volume of Local Anesthetic in Patients Undergoing Ultrasound-Guided Infraclavicular Approach for Brachial Plexus Blockade","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2015-11-01","conditions":"Underdosing of Local Anesthetics, Anesthetics, Local, Peripheral Nervous System Agents","enrollment":48},{"nctId":"NCT02188394","phase":"PHASE2","title":"Anesthetic Blockades and Migraine","status":"COMPLETED","sponsor":"César Fernández-de-las-Peñas","startDate":"2014-07","conditions":"Chronic Migraine, Pain","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Anesthetic blockades with bupivacaine","genericName":"Anesthetic blockades with bupivacaine","companyName":"César Fernández-de-las-Peñas","companyId":"c-sar-fern-ndez-de-las-pe-as","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses. Used for Postoperative pain management, Pain management during labor and delivery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}