{"id":"androstenediol","rwe":[{"pmid":"41762488","year":"2026","title":"LC-MS/MS-based simultaneous high-sensitivity quantification of clinically relevant high-potency androgens and estrogens in plasma and serum.","finding":"","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","studyType":"Clinical Study"},{"pmid":"41297875","year":"2026","title":"Developmental programming: gestational exposure to excess testosterone disrupts maternal steroid homeostasis and perturbs the steroid-lipid relationship in sheep.","finding":"","journal":"Molecular and cellular endocrinology","studyType":"Clinical Study"},{"pmid":"41184627","year":"2026","title":"Steroid hormone metabolites and mammographic breast density in premenopausal women.","finding":"","journal":"British journal of cancer","studyType":"Clinical Study"},{"pmid":"41102584","year":"2025","title":"Causal association of circulating metabolites with female infertility: a bidirectional mendelian randomization analysis.","finding":"","journal":"Metabolomics : Official journal of the Metabolomic Society","studyType":"Clinical Study"},{"pmid":"40888518","year":"2025","title":"Plasma metabolic landscape unveils key regulators of leukemia subtype progression.","finding":"","journal":"Future science OA","studyType":"Clinical Study"}],"tags":[{"label":"androstenediol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sex hormone-binding globulin","category":"target"},{"label":"SHBG","category":"gene"},{"label":"ESR2","category":"gene"},{"label":"ESR1","category":"gene"},{"label":"Active","category":"status"},{"label":"Anabolic Agents","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"hermaphrodiol","offLabel":[],"synonyms":["androstenediol","Androst-5-enediol","hermaphrodiol"],"timeline":[],"brandName":"Hermaphrodiol","ecosystem":[],"mechanism":{"target":"Corticosteroid-binding globulin, Sex hormone-binding globulin, Androgen receptor","targets":[{"gene":"SHBG","source":"DrugCentral","target":"Sex hormone-binding globulin","protein":"Sex hormone-binding globulin"},{"gene":"ESR2","source":"DrugCentral","target":"Estrogen receptor beta","protein":"Estrogen receptor beta"},{"gene":"ESR1","source":"DrugCentral","target":"Estrogen receptor","protein":"Estrogen receptor"},{"gene":"AR","source":"DrugCentral","target":"Androgen receptor","protein":"Androgen receptor"},{"gene":"SERPINA6","source":"DrugCentral","target":"Corticosteroid-binding globulin","protein":"Corticosteroid-binding globulin"}],"modality":"Small Molecule","drugClass":"androstenediol","explanation":"Think of sex hormone-binding globulin like a 'lock' that holds onto sex hormones, like a key. Hermaphrodiol is like a 'key' that binds to this 'lock', releasing the sex hormones and allowing them to do their job. This can help increase the levels of sex hormones in the body.","oneSentence":"Hermaphrodiol works by binding to sex hormone-binding globulin, a protein that regulates the levels of sex hormones in the body.","technicalDetail":"Hermaphrodiol binds to sex hormone-binding globulin (SHBG) with high affinity, displacing endogenous sex hormones and increasing their bioavailability for peripheral tissues."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/214","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=androstenediol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:43:55.715010","biosimilars":[],"competitors":[{"drugName":"bazedoxifene","drugSlug":"bazedoxifene","fdaApproval":"2013-10-03","relationship":"same-target"},{"drugName":"chlorotrianisene","drugSlug":"chlorotrianisene","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"clomifene","drugSlug":"clomifene","fdaApproval":"1967-02-01","relationship":"same-target"},{"drugName":"conjugated estrogens","drugSlug":"conjugated-estrogens","fdaApproval":"1942-05-08","relationship":"same-target"},{"drugName":"danazol","drugSlug":"danazol","fdaApproval":"1976-06-21","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"dienestrol","drugSlug":"dienestrol","fdaApproval":"1947-01-09","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"diethylstilbestrol","drugSlug":"diethylstilbestrol","fdaApproval":"1973-05-30","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"elacestrant","drugSlug":"elacestrant","fdaApproval":"2023-01-27","patentExpiry":"Oct 3, 2036","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"estetrol","drugSlug":"estetrol","fdaApproval":"2021-04-15","relationship":"same-target"},{"drugName":"estradiol","drugSlug":"estradiol","fdaApproval":"1975-07-23","patentExpiry":"Nov 21, 2032","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"androstenediol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"bazedoxifene","brandName":"bazedoxifene","genericName":"bazedoxifene","approvalYear":"2013","relationship":"same-target"},{"drugId":"chlorotrianisene","brandName":"chlorotrianisene","genericName":"chlorotrianisene","approvalYear":"","relationship":"same-target"},{"drugId":"clomifene","brandName":"clomifene","genericName":"clomifene","approvalYear":"1967","relationship":"same-target"},{"drugId":"conjugated-estrogens","brandName":"conjugated estrogens","genericName":"conjugated estrogens","approvalYear":"1942","relationship":"same-target"},{"drugId":"danazol","brandName":"danazol","genericName":"danazol","approvalYear":"1976","relationship":"same-target"},{"drugId":"dienestrol","brandName":"dienestrol","genericName":"dienestrol","approvalYear":"1947","relationship":"same-target"},{"drugId":"diethylstilbestrol","brandName":"diethylstilbestrol","genericName":"diethylstilbestrol","approvalYear":"1973","relationship":"same-target"},{"drugId":"elacestrant","brandName":"elacestrant","genericName":"elacestrant","approvalYear":"2023","relationship":"same-target"},{"drugId":"estetrol","brandName":"estetrol","genericName":"estetrol","approvalYear":"2021","relationship":"same-target"},{"drugId":"estradiol","brandName":"estradiol","genericName":"estradiol","approvalYear":"1975","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"95PS51EMXY","CHEBI":"CHEBI:2710","UMLSCUI":"C0524764","ChEMBL_ID":"CHEMBL440283","KEGG_DRUG":"D00179","DRUGBANK_ID":"DB01524","PDB_CHEM_ID":"B81","PUBCHEM_CID":"10634","SNOMEDCT_US":"103051007","MESH_DESCRIPTOR_UI":"D015114"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":531,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Apr 15","pmid":"41762488","title":"LC-MS/MS-based simultaneous high-sensitivity quantification of clinically relevant high-potency androgens and estrogens in plasma and serum.","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences"},{"date":"2026 Mar","pmid":"41297875","title":"Developmental programming: gestational exposure to excess testosterone disrupts maternal steroid homeostasis and perturbs the steroid-lipid relationship in sheep.","journal":"Molecular and cellular endocrinology"},{"date":"2026 Jan","pmid":"41184627","title":"Steroid hormone metabolites and mammographic breast density in premenopausal women.","journal":"British journal of cancer"},{"date":"2025 Oct 16","pmid":"41102584","title":"Causal association of circulating metabolites with female infertility: a bidirectional mendelian randomization analysis.","journal":"Metabolomics : Official journal of the Metabolomic Society"},{"date":"2025 Dec","pmid":"40888518","title":"Plasma metabolic landscape unveils key regulators of leukemia subtype progression.","journal":"Future science OA"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Androstenediol is an endogenous steroid hormone that serves as an intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA). It is a weak androgen and estrogen, closely related to androstenedione.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}