{"id":"androstanolone","rwe":[],"tags":[{"label":"androstanolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sex hormone-binding globulin","category":"target"},{"label":"SHBG","category":"gene"},{"label":"AR","category":"gene"},{"label":"CYP19A1","category":"gene"},{"label":"A14AA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Anemia of chronic renal failure","category":"indication"},{"label":"Catabolic Process","category":"indication"},{"label":"Androgens","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[],"contraindications":["Arteriosclerotic vascular disease","Benign prostatic hyperplasia","Blood coagulation disorder","Body fluid retention","Breast Carcinoma in Males","Breastfeeding (mother)","Cholestatic hepatitis","Decompensated cardiac failure","Diabetes mellitus","Disease of liver","Disorder of coronary artery","Edema","Heart disease","Heart failure","Humoral hypercalcemia of malignancy","Hypercalcemia","Hypercholesterolemia","Hypoalphalipoproteinemia","Kidney disease","Myocardial infarction","Neoplasm of liver","Neoplasm of prostate","Nephrotic syndrome","Obstruction of bile duct","Peliosis hepatis"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"neodrol","offLabel":[],"synonyms":["neodrol","androstanolone","androlone","dihydrotestosterone","stanolone"],"timeline":[],"brandName":"Neodrol","ecosystem":[{"indication":"Anemia of chronic renal failure","otherDrugs":[],"globalPrevalence":null},{"indication":"Catabolic Process","otherDrugs":[{"name":"oxandrolone","slug":"oxandrolone","company":"Crealta Pharms Llc"}],"globalPrevalence":null}],"mechanism":{"target":"Sex hormone-binding globulin","targets":[{"gene":"SHBG","source":"DrugCentral","target":"Sex hormone-binding globulin","protein":"Sex hormone-binding globulin"},{"gene":"AR","source":"DrugCentral","target":"Androgen receptor","protein":"Androgen receptor"},{"gene":"CYP19A1","source":"DrugCentral","target":"Aromatase","protein":"Aromatase"},{"gene":"NR3C2","source":"DrugCentral","target":"Mineralocorticoid receptor","protein":"Mineralocorticoid receptor"},{"gene":"NR3C1","source":"DrugCentral","target":"Glucocorticoid receptor","protein":"Glucocorticoid receptor"},{"gene":"SERPINA6","source":"DrugCentral","target":"Corticosteroid-binding globulin","protein":"Corticosteroid-binding globulin"},{"gene":"PGR","source":"DrugCentral","target":"Progesterone receptor","protein":"Progesterone receptor"}],"modality":"Small Molecule","drugClass":"androstanolone","explanation":"Think of it like a key fitting into a lock. Neodrol is a small molecule that fits into androgen receptors, which are like locks on cells. When it binds, it triggers a response that helps build muscle and increase energy, similar to how testosterone works in the body.","oneSentence":"Neodrol works by binding to androgen receptors, mimicking the effects of natural androgens like testosterone.","technicalDetail":"Neodrol, a synthetic androstanolone, exerts its effects by competitively binding to androgen receptors, thereby activating downstream signaling pathways that regulate protein synthesis, muscle growth, and erythropoiesis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3927","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=androstanolone","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:47:44.398776","biosimilars":[],"competitors":[{"drugName":"stanozolol","drugSlug":"stanozolol","fdaApproval":"1962-01-09","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"oxymetholone","drugSlug":"oxymetholone","fdaApproval":"1972-01-18","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"prasterone","drugSlug":"prasterone","fdaApproval":"","patentExpiry":"Mar 19, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"oxandrolone","drugSlug":"oxandrolone","fdaApproval":"1964-07-21","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"androstanolone","indications":{"approved":[{"name":"Anemia of chronic renal failure","source":"DrugCentral","snomedId":49708008,"regulator":"FDA"},{"name":"Catabolic Process","source":"DrugCentral","snomedId":"","regulator":"FDA"}],"offLabel":[{"name":"Congenital hypoplastic anemia","source":"DrugCentral","drugName":"androstanolone"},{"name":"Hb SS disease","source":"DrugCentral","drugName":"androstanolone","evidenceCount":1,"evidenceLevel":"emerging"},{"name":"Turner syndrome","source":"DrugCentral","drugName":"androstanolone","evidenceCount":19,"evidenceLevel":"moderate"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"stanozolol","brandName":"stanozolol","genericName":"stanozolol","approvalYear":"1962","relationship":"same-class"},{"drugId":"oxymetholone","brandName":"oxymetholone","genericName":"oxymetholone","approvalYear":"1972","relationship":"same-class"},{"drugId":"prasterone","brandName":"prasterone","genericName":"prasterone","approvalYear":"","relationship":"same-class"},{"drugId":"oxandrolone","brandName":"oxandrolone","genericName":"oxandrolone","approvalYear":"1964","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003255","UNII":"08J2K08A3Y","CHEBI":"CHEBI:16330","INN_ID":"238","UMLSCUI":"C0038148","ChEMBL_ID":"CHEMBL27769","KEGG_DRUG":"D07456","DRUGBANK_ID":"DB02901","PDB_CHEM_ID":"DHT","PUBCHEM_CID":"10635","SNOMEDCT_US":"103042004","IUPHAR_LIGAND_ID":"2856","MESH_DESCRIPTOR_UI":"D013196"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":70,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"A14AA01","allCodes":["A14AA01","G03BB02"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Neodrol, also known as androstanolone, is a synthetic androgen steroid developed for the treatment of anemia of chronic renal failure and catabolic processes. It works by targeting sex hormone-binding globulin, a protein that binds to androgens, thereby increasing their availability in the body. As a small molecule androstanolone, Neodrol is not FDA-approved for any indications, but it has been used off-label for its anabolic and androgenic effects. The commercial status of Neodrol is unclear, but it is likely to be off-patent. Key safety considerations include potential virilizing effects and interactions with other medications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}