{"id":"androgen-hormonal-suppression-and-radiation","safety":{"commonSideEffects":[{"rate":"50-80","effect":"Hot flashes"},{"rate":"70-90","effect":"Erectile dysfunction"},{"rate":"40-60","effect":"Fatigue"},{"rate":"20-40","effect":"Bowel toxicity (diarrhea, rectal irritation)"},{"rate":"30-50","effect":"Urinary symptoms (frequency, urgency)"},{"rate":"10-20","effect":"Gynecomastia"},{"rate":"60-80","effect":"Decreased libido"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Androgen deprivation therapy (ADT) blocks testosterone production or androgen receptor signaling, which slows growth of androgen-dependent prostate cancer. Concurrent radiation therapy delivers high-energy beams to the tumor site to cause direct DNA damage and cell death. The combination aims to improve local control and overall survival in advanced prostate cancer by targeting both hormonal dependence and tumor burden.","oneSentence":"This combination therapy suppresses androgen signaling in prostate cancer cells while using radiation to directly damage tumor DNA and kill cancer cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:42:44.650Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Locally advanced or high-risk prostate cancer (in combination with external beam radiation therapy)"}]},"trialDetails":[{"nctId":"NCT00328614","phase":"PHASE1","title":"Samarium-153 With Neoadjuvant Hormonal and Radiation Therapy for Locally Advanced Prostate Cancer","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University","startDate":"2003-03","conditions":"Prostate Cancer","enrollment":32},{"nctId":"NCT00116142","phase":"PHASE3","title":"Hormone Suppression and Radiation Therapy for 6 Months With/Without Docetaxel for High Risk Prostate Cancer","status":"COMPLETED","sponsor":"Dana-Farber Cancer Institute","startDate":"2005-06","conditions":"Prostate Cancer","enrollment":350},{"nctId":"NCT00116220","phase":"PHASE3","title":"Study of External Beam Radiation Therapy With and Without Hormonal Therapy to Treat Prostate Cancer","status":"COMPLETED","sponsor":"Dana-Farber Cancer Institute","startDate":"1995-09","conditions":"Prostate Cancer","enrollment":206},{"nctId":"NCT01230905","phase":"PHASE4","title":"Study to Monitor the Effects of Androgen Suppression Treatment on the Heart","status":"COMPLETED","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2008-07","conditions":"Prostate Cancer","enrollment":181},{"nctId":"NCT00767286","phase":"PHASE3","title":"Goserelin, Flutamine, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer","status":"COMPLETED","sponsor":"Radiation Therapy Oncology Group","startDate":"","conditions":"Prostate Cancer","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":40,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Androgen Hormonal Suppression and Radiation","genericName":"Androgen Hormonal Suppression and Radiation","companyName":"Dana-Farber Cancer Institute","companyId":"dana-farber-cancer-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy suppresses androgen signaling in prostate cancer cells while using radiation to directly damage tumor DNA and kill cancer cells. Used for Locally advanced or high-risk prostate cancer (in combination with external beam radiation therapy).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}