{"id":"analgesic-antipyretic-and-antihistamine-drugs","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1628401","moleculeType":"Small molecule","molecularWeight":"657.81"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Analgesic/antipyretic agents work by inhibiting prostaglandin synthesis (typically via COX inhibition) to reduce pain and fever, while antihistamines competitively block H1 or H2 histamine receptors to prevent allergic and inflammatory responses. The combination allows simultaneous treatment of pain, fever, and allergy symptoms in a single formulation.","oneSentence":"This is a combination drug class that reduces pain and fever through analgesic/antipyretic action while simultaneously blocking histamine receptors to reduce allergic responses.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:42:36.189Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain and fever with concurrent allergic symptoms"},{"name":"Cold and flu symptoms with allergy component"}]},"trialDetails":[{"nctId":"NCT01024036","phase":"PHASE2","title":"A Study to Evaluate the Efficacy and Safety of CNTO328 Plus Best Supportive Care in Multicentric Castleman's Disease","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2010-03-18","conditions":"Multicentric Castleman's Disease","enrollment":79},{"nctId":"NCT00719472","phase":"PHASE3","title":"A Study of Rituximab Alternative Dosing Rate in Patients With Previously Untreated Diffuse Large B-cell or Follicular Non-Hodgkin's Lymphoma (RATE)","status":"COMPLETED","sponsor":"Genentech, Inc.","startDate":"2008-07","conditions":"Non-Hodgkin's Lymphoma","enrollment":451}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Analgesic/antipyretic and antihistamine drugs","genericName":"Analgesic/antipyretic and antihistamine drugs","companyName":"Genentech, Inc.","companyId":"genentech-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination drug class that reduces pain and fever through analgesic/antipyretic action while simultaneously blocking histamine receptors to reduce allergic responses. Used for Pain and fever with concurrent allergic symptoms, Cold and flu symptoms with allergy component.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}