{"id":"anagrelide-cr","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"5-10%","effect":"Palpitations"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Anagrelide CR is a platelet aggregation inhibitor that acts by blocking the action of cyclic adenosine monophosphate (cAMP) on platelets, leading to a decrease in platelet count. This mechanism is thought to be responsible for its therapeutic effects in reducing the risk of thrombotic events.","oneSentence":"Anagrelide CR works by inhibiting platelet aggregation and reducing platelet count.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:09:12.904Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Essential thrombocythemia"}]},"trialDetails":[{"nctId":"NCT02125318","phase":"PHASE2","title":"A Study of Anagrelide Controlled Release (GALE-401) in Patients With High Platelet Counts Due to Bone Marrow Disorders","status":"COMPLETED","sponsor":"Galena Biopharma, Inc.","startDate":"2014-05","conditions":"Thrombocytosis, Myeloproliferative Neoplasms","enrollment":18}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GALE-401"],"phase":"phase_2","status":"active","brandName":"Anagrelide CR","genericName":"Anagrelide CR","companyName":"Galena Biopharma, Inc.","companyId":"galena-biopharma-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Anagrelide CR works by inhibiting platelet aggregation and reducing platelet count. Used for Essential thrombocythemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}