{"id":"an2728-topical-ointment-2-bid","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Application site reactions"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL2108523","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By inhibiting JAK enzymes, AN2728 reduces the production of pro-inflammatory cytokines, thereby alleviating symptoms of psoriasis. This mechanism of action is specific to the treatment of moderate to severe plaque psoriasis. AN2728's efficacy in this indication has been demonstrated in clinical trials.","oneSentence":"AN2728 is a topical ointment that targets the Janus kinase (JAK) pathway to modulate inflammation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:09:06.800Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe plaque psoriasis"}]},"trialDetails":[{"nctId":"NCT04194814","phase":"PHASE2","title":"Skin bioMARkers for Atopic Eczema Therapy Evaluation","status":"COMPLETED","sponsor":"Sheffield Teaching Hospitals NHS Foundation Trust","startDate":"2020-11-20","conditions":"Atopic Eczema/Dermatitis (Non-Specific)","enrollment":37},{"nctId":"NCT05298033","phase":"PHASE2","title":"Study of Efficacy, Safety and Tolerability of Crisaborole and PF-07038124 With and Without NBUVB in Vitiligo","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2022-09-07","conditions":"Vitiligo","enrollment":32},{"nctId":"NCT04023084","phase":"PHASE4","title":"Response of Children With Atopic Dermatitis (Eczema) to Eucrisa","status":"COMPLETED","sponsor":"Ann & Robert H Lurie Children's Hospital of Chicago","startDate":"2019-10-03","conditions":"Atopic Dermatitis, Eczema","enrollment":30},{"nctId":"NCT03539601","phase":"PHASE4","title":"A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD","status":"TERMINATED","sponsor":"Pfizer","startDate":"2018-04-27","conditions":"Atopic Dermatitis","enrollment":237},{"nctId":"NCT04008784","phase":"","title":"Improvement of Short Term Outcome of Mild to Moderate Atopic Dermatitis Using a Combination of Crisaborole and a Concomitant Topical Corticosteroid Over a 8 Week Period","status":"COMPLETED","sponsor":"Clinical Research Center of the Carolinas","startDate":"2019-09-16","conditions":"Atopic Dermatitis","enrollment":16},{"nctId":"NCT03351114","phase":"PHASE2","title":"Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea","status":"COMPLETED","sponsor":"Duke University","startDate":"2018-09-01","conditions":"Morphea","enrollment":8},{"nctId":"NCT03233529","phase":"PHASE2","title":"Crisaborole Ointment 2% Skin Biomarker Biopsy Study in Atopic Dermatitis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2017-07-31","conditions":"Dermatitis, Atopic","enrollment":40},{"nctId":"NCT01301508","phase":"PHASE2","title":"Efficacy and Safety of AN2898 and AN2728 Topical Ointments to Treat Mild-to-Moderate Atopic Dermatitis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2011-05","conditions":"Dermatitis, Atopic","enrollment":46},{"nctId":"NCT01652885","phase":"PHASE1, PHASE2","title":"Safety, Tolerability, and PK of AN2728 in Adolescents With Atopic Dermatitis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2012-07","conditions":"Dermatitis, Atopic","enrollment":23},{"nctId":"NCT01300052","phase":"PHASE2","title":"AN2728 Topical Ointment to Treat Mild-to-Moderate Plaque-Type Psoriasis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2011-01-26","conditions":"Psoriasis","enrollment":68},{"nctId":"NCT01029405","phase":"PHASE2","title":"Safety and Efficacy Study of a Novel Ointment to Treat Plaque Type Psoriasis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2009-11","conditions":"Psoriasis","enrollment":145},{"nctId":"NCT01602341","phase":"PHASE2","title":"Efficacy and Safety of AN2728 Topical Ointment to Treat Adolescents With Atopic Dermatitis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2012-08","conditions":"Dermatitis, Atopic","enrollment":86},{"nctId":"NCT00755196","phase":"PHASE2","title":"Safety and Efficacy Study of A Novel Ointment to Treat Plaque Type Psoriasis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2008-09","conditions":"Psoriasis","enrollment":30},{"nctId":"NCT02118766","phase":"PHASE3","title":"Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Ages 2 Years and Older) With Atopic Dermatitis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2014-03","conditions":"Dermatitis, Atopic","enrollment":763},{"nctId":"NCT02118792","phase":"PHASE3","title":"Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Aged 2 Years and Older) With Atopic Dermatitis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2014-03","conditions":"Dermatitis, Atopic","enrollment":764},{"nctId":"NCT00759161","phase":"PHASE2","title":"Safety and Efficacy Study of A Novel Ointment to Treat Plaque Type Psoriasis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2007-11","conditions":"Psoriasis","enrollment":35}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"AN2728 Topical Ointment, 2% BID","genericName":"AN2728 Topical Ointment, 2% BID","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AN2728 is a topical ointment that targets the Janus kinase (JAK) pathway to modulate inflammation. Used for Moderate to severe plaque psoriasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}