{"id":"an2728-topical-ointment-0-5-qd","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site irritation"},{"rate":null,"effect":"Application site burning"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"PDE4 inhibition increases intracellular cAMP levels, which suppresses the production of pro-inflammatory mediators such as TNF-α and IL-23 in immune and skin cells. This mechanism reduces the inflammatory cascade underlying psoriasis and other inflammatory skin conditions. The topical formulation delivers the drug directly to affected skin with minimal systemic exposure.","oneSentence":"AN2728 is a phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in skin cells when applied topically.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T04:09:14.771Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Psoriasis (topical treatment)"},{"name":"Atopic dermatitis (topical treatment)"}]},"trialDetails":[{"nctId":"NCT01602341","phase":"PHASE2","title":"Efficacy and Safety of AN2728 Topical Ointment to Treat Adolescents With Atopic Dermatitis","status":"COMPLETED","sponsor":"Pfizer","startDate":"2012-08","conditions":"Dermatitis, Atopic","enrollment":86}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"AN2728 Topical Ointment, 0.5% QD","genericName":"AN2728 Topical Ointment, 0.5% QD","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AN2728 is a phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in skin cells when applied topically. Used for Psoriasis (topical treatment), Atopic dermatitis (topical treatment).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}