{"id":"an-extract-of-cimicifuga-foetida-l","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cimicifuga foetida (black cohosh relative) contains phytoestrogens and other bioactive compounds that may act as selective estrogen receptor modulators or modulate serotonergic and GABAergic pathways. The extract is believed to reduce vasomotor symptoms and mood disturbances associated with menopause through these multiple mechanisms rather than direct estrogen replacement.","oneSentence":"An herbal extract from Cimicifuga foetida that modulates estrogen-related pathways and inflammatory responses, traditionally used to manage menopausal symptoms.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:42:26.711Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal symptoms (hot flashes, night sweats, mood disturbances)"}]},"trialDetails":[{"nctId":"NCT00622986","phase":"PHASE4","title":"China Cimicifuga Trial of Climacteric Complaint Control","status":"UNKNOWN","sponsor":"Shandong Luye Pharmaceutical Co., Ltd.","startDate":"2008-02","conditions":"Climacteric Symptoms","enrollment":288}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ximingting"],"phase":"marketed","status":"active","brandName":"an extract of Cimicifuga Foetida L.","genericName":"an extract of Cimicifuga Foetida L.","companyName":"Shandong Luye Pharmaceutical Co., Ltd.","companyId":"shandong-luye-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"An herbal extract from Cimicifuga foetida that modulates estrogen-related pathways and inflammatory responses, traditionally used to manage menopausal symptoms. Used for Menopausal symptoms (hot flashes, night sweats, mood disturbances).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}