{"id":"amylocaine","rwe":[{"pmid":"31408041","year":"2019","title":"Antipodal Views on Branding Amylocaine as Stovaine: Modesty or Political Correctness?","finding":"","journal":"Anesthesiology","studyType":"Clinical Study"},{"pmid":"29194609","year":"2018","title":"Using the Connectivity Map to discover compounds influencing human osteoblast differentiation.","finding":"","journal":"Journal of cellular physiology","studyType":"Clinical Study"},{"pmid":"9068339","year":"1997","title":"Do local anaesthetics interact with dihydropyridine binding sites on neuronal L-type Ca2+ channels?","finding":"","journal":"British journal of anaesthesia","studyType":"Clinical Study"},{"pmid":"8357867","year":"1993","title":"Automatic determination of amylocaine and bromhexine by atomic absorption spectrometry.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"1400841","year":"1992","title":"Determination of limiting ionic mobilities and dissociation constants of some local anaesthetics.","finding":"","journal":"Journal of chromatography","studyType":"Clinical Study"}],"tags":[{"label":"amylocaine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"amyleine","offLabel":[],"synonyms":["amylocaine","amyleine","stovaine","amylocaine hydrochloride","amyleine hydrochloride","amylocaine HCl","amyleine HCl"],"timeline":[],"brandName":"Amyleine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"amylocaine","explanation":"Imagine your nerves are like a telephone line, and pain signals are like phone calls. Amyleine acts like a switch that turns off the phone line, so the pain signals can't get through. This temporary blockage of pain signals is what allows amyleine to provide local anesthesia.","oneSentence":"Amyleine works by blocking sodium channels in nerve cells to prevent pain signals from being transmitted.","technicalDetail":"Amyleine exerts its anesthetic effect by reversibly binding to and blocking voltage-gated sodium channels, specifically the Nav1.7 subtype, which are responsible for the initiation and propagation of action potentials in sensory neurons."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/206","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=amylocaine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:43:31.103989","biosimilars":[],"competitors":[],"genericName":"amylocaine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003825","UNII":"QRW683O56T","CHEBI":"CHEBI:34981","RXNORM":"235793","UMLSCUI":"C0081580","ChEMBL_ID":"CHEMBL1740065","KEGG_DRUG":"D07454","DRUGBANK_ID":"DB09088","PUBCHEM_CID":"10767","SECONDARY_CAS_RN":"532-59-2","MESH_SUPPLEMENTAL_RECORD_UI":"C015677"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2019 Sep","pmid":"31408041","title":"Antipodal Views on Branding Amylocaine as Stovaine: Modesty or Political Correctness?","journal":"Anesthesiology"},{"date":"2018 Jun","pmid":"29194609","title":"Using the Connectivity Map to discover compounds influencing human osteoblast differentiation.","journal":"Journal of cellular physiology"},{"date":"1997 Feb","pmid":"9068339","title":"Do local anaesthetics interact with dihydropyridine binding sites on neuronal L-type Ca2+ channels?","journal":"British journal of anaesthesia"},{"date":"1993 Apr-May","pmid":"8357867","title":"Automatic determination of amylocaine and bromhexine by atomic absorption spectrometry.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"1992 Apr 10","pmid":"1400841","title":"Determination of limiting ionic mobilities and dissociation constants of some local anaesthetics.","journal":"Journal of chromatography"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Amylocaine, also known as Stovaine, is a synthetic local anesthetic that was the first of its kind, synthesized and patented by Ernest Fourneau in 1903. It was primarily used in spinal anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}