{"id":"amylase-resistant-starch-added-ors","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal bloating"},{"rate":null,"effect":"Flatulence"},{"rate":null,"effect":"Mild abdominal discomfort"}]},"_chembl":{"chemblId":"CHEMBL2108866","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amylase-resistant starch (ARS) is a carbohydrate that resists enzymatic digestion in the small intestine and reaches the colon intact. There it undergoes bacterial fermentation, producing short-chain fatty acids (particularly butyrate) that enhance colonic water and electrolyte absorption. This mechanism reduces stool output and improves the efficacy of oral rehydration therapy in acute diarrhea.","oneSentence":"Amylase-resistant starch in oral rehydration solution reduces stool output and improves water absorption in diarrheal disease by providing a slowly fermentable carbohydrate substrate.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:01:20.836Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute diarrhea (cholera and non-cholera)"},{"name":"Diarrheal disease in children"}]},"trialDetails":[{"nctId":"NCT00324285","phase":"PHASE3","title":"Oral Rehydration SolutionContaining Amylase Resistant Starch in Severely Malnourished Children.","status":"COMPLETED","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2001-07","conditions":"Diarrhoea, Severe Malnutrition","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Amylase resistant starch added ORS","genericName":"Amylase resistant starch added ORS","companyName":"International Centre for Diarrhoeal Disease Research, Bangladesh","companyId":"international-centre-for-diarrhoeal-disease-research-bangladesh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amylase-resistant starch in oral rehydration solution reduces stool output and improves water absorption in diarrheal disease by providing a slowly fermentable carbohydrate substrate. Used for Acute diarrhea (cholera and non-cholera), Diarrheal disease in children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}