{"id":"amphotericin-b-lipid-emulsion","safety":{"commonSideEffects":[{"rate":"20-80","effect":"Nephrotoxicity (elevated creatinine, reduced GFR)"},{"rate":"50-90","effect":"Infusion-related reactions (fever, chills, rigors)"},{"rate":"25-50","effect":"Hypokalemia"},{"rate":"20-40","effect":"Anemia"},{"rate":"15-30","effect":"Hypomagnesemia"},{"rate":"10-25","effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amphotericin B is a polyene antifungal that selectively targets ergosterol, a sterol unique to fungal cell membranes. By binding to ergosterol, it forms ion channels that increase membrane permeability, leading to leakage of cellular contents and fungal cell death. The lipid emulsion formulation reduces nephrotoxicity by altering the drug's distribution and reducing binding to human cell membranes.","oneSentence":"Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and cause cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:01:29.055Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Systemic fungal infections (invasive aspergillosis, candidiasis, cryptococcosis)"},{"name":"Amphotericin B-susceptible fungal infections in immunocompromised patients"}]},"trialDetails":[{"nctId":"NCT00876824","phase":"PHASE3","title":"To Study the Effect Of Single Infusions Of Amphotericin B Lipid Preparations in Treatment of Patients Of Kala Azar","status":"COMPLETED","sponsor":"Bharat Serums and Vaccines Limited","startDate":"2009-07","conditions":"Leishmaniasis, Visceral","enrollment":500}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Amphomul"],"phase":"phase_3","status":"active","brandName":"Amphotericin B Lipid emulsion","genericName":"Amphotericin B Lipid emulsion","companyName":"Bharat Serums and Vaccines Limited","companyId":"bharat-serums-and-vaccines-limited","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and cause cell death. Used for Systemic fungal infections (invasive aspergillosis, candidiasis, cryptococcosis), Amphotericin B-susceptible fungal infections in immunocompromised patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}