{"id":"amphenidone","rwe":[{"pmid":"13983756","year":"1963","title":"An EEG and behavioral analysis of the anticonvulsant action of amphenidone (I) in the rabbit.","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"14038388","year":"1962","title":"Antithyroid activity of amphenidone.","finding":"","journal":"The Journal of clinical endocrinology and metabolism","studyType":"Clinical Study"},{"pmid":"13902295","year":"1961","title":"Agranulocytosis due to amphenidone.","finding":"","journal":"American practitioner and digest of treatment","studyType":"Clinical Study"},{"pmid":"13685432","year":"1961","title":"The effect of amphenidone (Dornwal) in anxiety states: a multi-blind study.","finding":"","journal":"The American journal of psychiatry","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"amfenidone","offLabel":[],"synonyms":["amphenidone","amfenidone"],"timeline":[],"brandName":"Amfenidone","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells have locks on them, and the key to unlocking the right response is a specific molecule. Amfenidone is designed to fit that key, allowing it to turn the lock and trigger a response that can help treat a particular condition. However, the exact details of how it works are still unclear.","oneSentence":"Amfenidone is thought to work by interacting with a specific molecular target to produce a therapeutic effect.","technicalDetail":"Amfenidone's mechanism of action is not well understood, but it is believed to involve modulation of a specific molecular pathway, potentially through interaction with a receptor or enzyme."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/194","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AMPHENIDONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:44:34.000964","biosimilars":[],"competitors":[],"genericName":"amphenidone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"M61FM2VCSV","CHEBI":"CHEBI:134830","INN_ID":"928","UMLSCUI":"C2698099","ChEMBL_ID":"CHEMBL2104057","PUBCHEM_CID":"8641"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1963 Mar 1","pmid":"13983756","title":"An EEG and behavioral analysis of the anticonvulsant action of amphenidone (I) in the rabbit.","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1962 Jan","pmid":"14038388","title":"Antithyroid activity of amphenidone.","journal":"The Journal of clinical endocrinology and metabolism"},{"date":"1961 Nov","pmid":"13902295","title":"Agranulocytosis due to amphenidone.","journal":"American practitioner and digest of treatment"},{"date":"1961 Aug","pmid":"13685432","title":"The effect of amphenidone (Dornwal) in anxiety states: a multi-blind study.","journal":"The American journal of psychiatry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amfenidone is a small molecule with synonyms including Amfenidona and Amphenidone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}