{"id":"amoxicillin-st14","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Diarrhea"},{"rate":"3-5","effect":"Nausea"},{"rate":"1-3","effect":"Rash"},{"rate":"0.1-1","effect":"Allergic reaction / Anaphylaxis"},{"rate":"1-3","effect":"Vomiting"}]},"_chembl":{"chemblId":"CHEMBL2105950","moleculeType":"Small molecule","molecularWeight":"387.39"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amoxicillin is a beta-lactam antibiotic that penetrates bacterial cell walls and irreversibly binds to penicillin-binding proteins (PBPs), preventing the cross-linking of peptidoglycan strands. This disrupts cell wall integrity, leading to bacterial cell lysis and death. It is bactericidal and effective against a broad spectrum of gram-positive and some gram-negative bacteria.","oneSentence":"Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and blocking peptidoglycan cross-linking.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:27:10.961Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections caused by susceptible organisms (respiratory tract infections, otitis media, sinusitis, urinary tract infections, skin and soft tissue infections)"},{"name":"Helicobacter pylori eradication (as part of combination therapy)"}]},"trialDetails":[{"nctId":"NCT03208426","phase":"PHASE4","title":"Sequential Versus Quadruple Therapy in the Second-line Treatment","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2017-10-01","conditions":"Helicobacter Pylori Infection","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["amoxicillin capsule"],"phase":"marketed","status":"active","brandName":"Amoxicillin (ST14)","genericName":"Amoxicillin (ST14)","companyName":"National Taiwan University Hospital","companyId":"national-taiwan-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and blocking peptidoglycan cross-linking. Used for Bacterial infections caused by susceptible organisms (respiratory tract infections, otitis media, sinusitis, urinary tract infections, skin and soft tissue infections), Helicobacter pylori eradication (as part of combination therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}