{"id":"amoxicillin-clavulunate-potassium","safety":{"commonSideEffects":[{"rate":"5-10%","effect":"Diarrhea"},{"rate":"3-5%","effect":"Nausea"},{"rate":"1-3%","effect":"Vomiting"},{"rate":"1-3%","effect":"Rash"},{"rate":"1-3%","effect":"Abdominal pain"},{"rate":"1-2%","effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amoxicillin works by binding to penicillin-binding proteins and inhibiting bacterial cell wall cross-linking, leading to cell lysis and death. Clavulanic acid is a beta-lactamase inhibitor that prevents bacterial enzymes from breaking down amoxicillin, thereby extending its spectrum of activity against beta-lactamase-producing organisms.","oneSentence":"Amoxicillin/clavulanate is a beta-lactam antibiotic combination that kills bacteria by inhibiting cell wall synthesis, with clavulanate protecting amoxicillin from degradation by bacterial beta-lactamases.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:44:32.024Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections caused by susceptible organisms including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and otitis media"}]},"trialDetails":[{"nctId":"NCT01370616","phase":"PHASE3","title":"Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2011-09-02","conditions":"Infection; Diabetic Foot","enrollment":565}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Amoxicillin/clavulunate potassium","genericName":"Amoxicillin/clavulunate potassium","companyName":"Merck Sharp & Dohme LLC","companyId":"merck","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amoxicillin/clavulanate is a beta-lactam antibiotic combination that kills bacteria by inhibiting cell wall synthesis, with clavulanate protecting amoxicillin from degradation by bacterial beta-lactamases. Used for Bacterial infections caused by susceptible organisms including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and otitis media.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}