{"id":"amoscanate","rwe":[{"pmid":"31580252","year":"2020","title":"Molecular Modeling and Docking of Aquaporin Inhibitors to Reveal New Insights into Schistosomiasis Treatment.","finding":"","journal":"Current computer-aided drug design","studyType":"Clinical Study"},{"pmid":"21189316","year":"2011","title":"The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread.","finding":"","journal":"Toxicologic pathology","studyType":"Clinical Study"},{"pmid":"20627145","year":"2010","title":"Research and development of antischistosomal drugs in the People's Republic of China a 60-year review.","finding":"","journal":"Advances in parasitology","studyType":"Clinical Study"},{"pmid":"12113767","year":"2002","title":"Mutagenicity of sulfoscanate: a comparative study.","finding":"","journal":"Mutation research","studyType":"Clinical Study"},{"pmid":"8096107","year":"1993","title":"Modulatory effects of antifilarial drugs ivermectin, CGP 6140 and CGP 20376 on the oxidative burst of eosinophilic granulocytes.","finding":"","journal":"Acta tropica","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anthelmintics","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antinematodal Agents","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiplatyhelmintic Agents","category":"pharmacology"},{"label":"Filaricides","category":"pharmacology"},{"label":"Schistosomicides","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"nithiocyamine","offLabel":[],"synonyms":["amoscanate","nithiocyamine","p-(p-Nitroanilino)phenyl isothiocyanate"],"timeline":[],"brandName":"Nithiocyamine","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like a city with many different buildings. Nithiocyamine is like a key that fits into a specific lock on one of those buildings, allowing it to send a signal that helps to treat a particular condition. This is a simplified way of describing how small molecules like Nithiocyamine work.","oneSentence":"Nithiocyamine works by binding to specific biological molecules to produce its therapeutic effect.","technicalDetail":"Nithiocyamine's exact mechanism of action is unknown, but as a small molecule, it is likely to work by interacting with specific receptors, enzymes, or other biological molecules to produce its therapeutic effect."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/189","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AMOSCANATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:42:16.393315","biosimilars":[],"competitors":[],"genericName":"amoscanate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"X0MK46CVRB","CHEBI":"CHEBI:38944","INN_ID":"4042","UMLSCUI":"C0051739","ChEMBL_ID":"CHEMBL93385","PUBCHEM_CID":"33488","MESH_SUPPLEMENTAL_RECORD_UI":"C012391"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2020","pmid":"31580252","title":"Molecular Modeling and Docking of Aquaporin Inhibitors to Reveal New Insights into Schistosomiasis Treatment.","journal":"Current computer-aided drug design"},{"date":"2011 Jan","pmid":"21189316","title":"The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread.","journal":"Toxicologic pathology"},{"date":"2010","pmid":"20627145","title":"Research and development of antischistosomal drugs in the People's Republic of China a 60-year review.","journal":"Advances in parasitology"},{"date":"2002 Jul 25","pmid":"12113767","title":"Mutagenicity of sulfoscanate: a comparative study.","journal":"Mutation research"},{"date":"1993 Mar","pmid":"8096107","title":"Modulatory effects of antifilarial drugs ivermectin, CGP 6140 and CGP 20376 on the oxidative burst of eosinophilic granulocytes.","journal":"Acta tropica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nithiocyamine, also known as AMOSCANATE, is a small molecule drug with unknown target and drug class. Its commercial status is unclear, and it has not been approved by the FDA for any indications. As a small molecule, it is likely to work by interacting with specific biological molecules to produce its therapeutic effect. Further information on its mechanism of action, safety considerations, and availability is not available. More research is needed to fully understand this compound.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}