{"id":"amorolfine-nail-lacquer","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It does this by interfering with the synthesis of ergosterol, an essential component of fungal cell membranes. This leads to the death of the fungal cells, effectively treating fungal infections of the nails.","oneSentence":"Amorolfine nail lacquer works by inhibiting the growth of fungi on the nail plate and nail bed.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:01:25.064Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of onychomycosis (fungal infection of the nails)"}]},"trialDetails":[{"nctId":"NCT02812043","phase":"PHASE4","title":"Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2016-08","conditions":"Non-dermatophyte Onychomycosis","enrollment":60},{"nctId":"NCT02679911","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2015-09","conditions":"Foot Dermatoses","enrollment":20},{"nctId":"NCT02705664","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2016-01","conditions":"Foot Dermatoses","enrollment":22},{"nctId":"NCT00938925","phase":"NA","title":"Effectiveness of Podiatry Care on Onychomycosis (EPOCAON)","status":"WITHDRAWN","sponsor":"University of Malaga","startDate":"2009-10","conditions":"Onychomycosis","enrollment":""},{"nctId":"NCT03098342","phase":"NA","title":"Comparison of Efficacy and Safety Between Methylene Blue-mediated Photodynamic Therapy and 5% Amorolfine Nail Lacquer for Toenail Onychomycosis Treatment","status":"UNKNOWN","sponsor":"Chulalongkorn University","startDate":"2017-06-01","conditions":"Onychomycosis of Toenail","enrollment":42},{"nctId":"NCT01851590","phase":"PHASE4","title":"Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2013-10","conditions":"Onychomycosis","enrollment":129},{"nctId":"NCT01929187","phase":"NA","title":"A Randomized Study to Evaluate the Efficacy of Herbal Ingredients Combined With a Carrier System (Phytonail) Compared With Amorolfine 5% Nail Lacquer (Loceryl) in the Treatment of Toenail Onychomycosis","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2013-02","conditions":"Onycomycosis","enrollment":72},{"nctId":"NCT00459537","phase":"PHASE3","title":"Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis","status":"COMPLETED","sponsor":"Novartis","startDate":"2007-03","conditions":"Onychomycosis","enrollment":1029},{"nctId":"NCT01014637","phase":"PHASE4","title":"Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis","status":"UNKNOWN","sponsor":"Pierre Fabre Dermo Cosmetique","startDate":"2009-08","conditions":"Onychomycosis","enrollment":260}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":26,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"amorolfine nail lacquer","genericName":"amorolfine nail lacquer","companyName":"Novartis","companyId":"novartis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amorolfine nail lacquer works by inhibiting the growth of fungi on the nail plate and nail bed. Used for Treatment of onychomycosis (fungal infection of the nails).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}