{"id":"amodiaquine-plus-sulphadoxine-pyrimethamine-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Stevens-Johnson syndrome (rare)"}]},"_chembl":{"chemblId":"CHEMBL682","moleculeType":"Small molecule","molecularWeight":"355.87"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amodiaquine is a 4-aminoquinoline that accumulates in parasite food vacuoles and disrupts hemoglobin digestion and DNA synthesis. Sulphadoxine-pyrimethamine inhibits sequential steps in folate metabolism (dihydropteroate synthase and dihydrofolate reductase), preventing nucleotide synthesis. Together, they provide additive antimalarial activity with reduced risk of resistance development compared to monotherapy.","oneSentence":"This combination inhibits parasite DNA synthesis and folate metabolism through two complementary antimalarial agents that work synergistically against Plasmodium parasites.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:27:05.809Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria caused by Plasmodium falciparum"},{"name":"Malaria treatment in endemic regions, particularly in sub-Saharan Africa"}]},"trialDetails":[{"nctId":"NCT07322068","phase":"PHASE4","title":"Perennial Malaria Chemoprevention in the Malaria Vaccine Era","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2026-09","conditions":"Malaria, Falciparum","enrollment":1290},{"nctId":"NCT00131703","phase":"PHASE3","title":"Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian 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Used for Uncomplicated malaria caused by Plasmodium falciparum, Malaria treatment in endemic regions, particularly in sub-Saharan Africa.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}