{"id":"amniotic-fluid-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Temporary increased inflammation"},{"rate":null,"effect":"Infection risk"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amniotic fluid contains growth factors, cytokines, and other bioactive molecules that may stimulate regeneration and modulate immune responses. When injected into damaged or degenerative tissues, these components are thought to promote healing, reduce inflammatory signaling, and potentially restore tissue function. The exact active constituents and their individual contributions remain under investigation.","oneSentence":"Amniotic fluid injection delivers bioactive components from amniotic fluid to promote tissue repair and reduce inflammation at the injection site.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:01:20.364Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis and joint degeneration (Phase 3)"}]},"trialDetails":[{"nctId":"NCT04886960","phase":"PHASE1, PHASE2","title":"pAF for the Treatment of Osteoarthritis","status":"COMPLETED","sponsor":"University of Utah","startDate":"2021-07-08","conditions":"Osteo Arthritis Knee","enrollment":60},{"nctId":"NCT07482423","phase":"PHASE1, PHASE2","title":"XVIE to Treat Androgenetic Alopecia (AGA)","status":"NOT_YET_RECRUITING","sponsor":"Restore Biologics Holdings, Inc. dba Xtressé","startDate":"2026-05-01","conditions":"Androgenetic 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Education","startDate":"2020-11-18","conditions":"Osteoarthritis, Knee","enrollment":90},{"nctId":"NCT04698265","phase":"NA","title":"Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis.","status":"UNKNOWN","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2021-01-01","conditions":"Knee Osteoarthristis","enrollment":150},{"nctId":"NCT03074526","phase":"NA","title":"Protocol for the Clinical Evaluation of Lyophilized Amniotic Fluid in the Treatment of Knee Osteoarthritis","status":"COMPLETED","sponsor":"MiMedx Group, Inc.","startDate":"2017-01-23","conditions":"Osteoarthritis, Knee","enrollment":156},{"nctId":"NCT04599673","phase":"PHASE4","title":"Prospective Analysis of Intraoperative AMNIOGEN® Injection in Patients With Rotator Cuff Tear","status":"UNKNOWN","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2020-10-15","conditions":"Rotator Cuff 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Used for Osteoarthritis and joint degeneration (Phase 3).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}