{"id":"amlodipine-telmisartan-amiloride-compound-simvastatin","safety":{"commonSideEffects":[{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Muscle pain or myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amlodipine blocks L-type calcium channels to relax vascular smooth muscle; telmisartan blocks AT1 angiotensin II receptors to reduce vasoconstriction and aldosterone secretion; amiloride inhibits epithelial sodium channels to promote sodium and water excretion while retaining potassium; simvastatin inhibits HMG-CoA reductase to reduce LDL cholesterol synthesis. Together these agents provide synergistic antihypertensive and cardioprotective effects.","oneSentence":"This fixed-dose combination reduces blood pressure and cardiovascular risk through calcium channel blockade, angiotensin II receptor antagonism, potassium-sparing diuresis, and cholesterol lowering.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:27:11.062Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension with dyslipidemia"},{"name":"Cardiovascular risk reduction in hypertensive patients"}]},"trialDetails":[{"nctId":"NCT01011660","phase":"PHASE4","title":"Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients","status":"UNKNOWN","sponsor":"Chinese Academy of Medical Sciences, Fuwai Hospital","startDate":"2007-10","conditions":"Essential Hypertension","enrollment":13542}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CHIEF"],"phase":"marketed","status":"active","brandName":"Amlodipine, Telmisartan, Amiloride Compound , Simvastatin","genericName":"Amlodipine, Telmisartan, Amiloride Compound , Simvastatin","companyName":"Chinese Academy of Medical Sciences, Fuwai Hospital","companyId":"chinese-academy-of-medical-sciences-fuwai-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This fixed-dose combination reduces blood pressure and cardiovascular risk through calcium channel blockade, angiotensin II receptor antagonism, potassium-sparing diuresis, and cholesterol lowering. Used for Hypertension with dyslipidemia, Cardiovascular risk reduction in hypertensive patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}