{"id":"amlodipine-plus-metformin","safety":{"commonSideEffects":[{"rate":"5–10","effect":"Peripheral edema"},{"rate":"5–7","effect":"Headache"},{"rate":"3–5","effect":"Flushing"},{"rate":"10–30","effect":"Gastrointestinal disturbance (metformin-related)"},{"rate":"3–5","effect":"Dizziness"},{"rate":"<0.1","effect":"Lactic acidosis (rare, metformin-related)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amlodipine is a dihydropyridine calcium channel blocker that relaxes vascular smooth muscle to lower blood pressure. Metformin is a biguanide that decreases hepatic gluconeogenesis and increases peripheral glucose uptake, improving insulin sensitivity. Together, they address both hypertension and hyperglycemia in patients with concurrent cardiovascular and metabolic disease.","oneSentence":"This combination reduces blood pressure through calcium channel blockade (amlodipine) while improving glucose control through enhanced insulin sensitivity and reduced hepatic glucose production (metformin).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:19.715Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension with type 2 diabetes mellitus"},{"name":"Cardiovascular risk reduction in patients with concurrent hypertension and hyperglycemia"}]},"trialDetails":[{"nctId":"NCT05660083","phase":"PHASE2","title":"Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)","status":"RECRUITING","sponsor":"The Methodist Hospital Research Institute","startDate":"2023-01-12","conditions":"HER2-negative Breast Cancer, Metastatic Breast Cancer, Metaplastic Breast Carcinoma","enrollment":36},{"nctId":"NCT04962841","phase":"","title":"Nutraceuticals and Drug Treatment in Frail Older Adults","status":"UNKNOWN","sponsor":"University of Campania Luigi Vanvitelli","startDate":"2020-04-01","conditions":"Frailty","enrollment":485},{"nctId":"NCT03489317","phase":"","title":"Gut Microbiomes in Patients With Metabolic Syndrome","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2017-11-27","conditions":"Metabolic Syndrome","enrollment":1000},{"nctId":"NCT00000620","phase":"PHASE3","title":"Action to Control Cardiovascular Risk in Diabetes (ACCORD)","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"1999-09","conditions":"Atherosclerosis, Cardiovascular Diseases, Hypercholesterolemia","enrollment":10251},{"nctId":"NCT00538486","phase":"PHASE4","title":"A Randomized, Double-Blind, Active Control Trial Comparing Effects of Telmisartan, Candesartan and Amlodipine, Alone or Plus Metformin, on Non-Diabetic, Obese Hypertensive Patients","status":"COMPLETED","sponsor":"Third Military Medical University","startDate":"2008-02","conditions":"Hypertension, Obesity","enrollment":360}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Amlodipine plus Metformin","genericName":"Amlodipine plus Metformin","companyName":"Third Military Medical University","companyId":"third-military-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces blood pressure through calcium channel blockade (amlodipine) while improving glucose control through enhanced insulin sensitivity and reduced hepatic glucose production (metformin). Used for Hypertension with type 2 diabetes mellitus, Cardiovascular risk reduction in patients with concurrent hypertension and hyperglycemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}