{"id":"amlodipine-intensive-antihypertensive-therapy","safety":{"commonSideEffects":[{"rate":"5-10%","effect":"Peripheral edema"},{"rate":"5-7%","effect":"Headache"},{"rate":"3-5%","effect":"Flushing"},{"rate":"2-4%","effect":"Dizziness"},{"rate":"2-3%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation and reduced peripheral vascular resistance. When used as intensive antihypertensive therapy (typically in combination with other agents such as ACE inhibitors, ARBs, or diuretics), it provides additive blood pressure reduction through complementary mechanisms of action.","oneSentence":"Amlodipine blocks L-type calcium channels in vascular smooth muscle to reduce blood pressure, often combined with other antihypertensive agents for enhanced efficacy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:19.714Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension (as part of intensive antihypertensive regimen)"},{"name":"Angina pectoris"}]},"trialDetails":[{"nctId":"NCT05609513","phase":"NA","title":"Integration of Hypertension Management in HIV Care in Uganda","status":"COMPLETED","sponsor":"Infectious Diseases Research Collaboration, Uganda","startDate":"2023-02-06","conditions":"HIV/AIDS, Hypertension","enrollment":87421},{"nctId":"NCT05331144","phase":"PHASE2","title":"Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)","status":"RECRUITING","sponsor":"Rong Zhang","startDate":"2022-10-25","conditions":"Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline","enrollment":180},{"nctId":"NCT03354143","phase":"PHASE2","title":"Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2018-04-10","conditions":"Hypertension","enrollment":85},{"nctId":"NCT06495710","phase":"NA","title":"Arterial Stiffness and Blood Pressure","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2025-05-01","conditions":"Hypertension, Vascular Stiffness, Aging","enrollment":228},{"nctId":"NCT03264352","phase":"PHASE4","title":"Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes","status":"RECRUITING","sponsor":"XueQing 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Decline","enrollment":513},{"nctId":"NCT05169021","phase":"PHASE4","title":"Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2021-12-31","conditions":"Cerebral Small Vessel Diseases, Stroke","enrollment":15000},{"nctId":"NCT00535925","phase":"PHASE4","title":"Nephropathy In Type 2 Diabetes and Cardio-renal Events","status":"COMPLETED","sponsor":"University of Campania Luigi Vanvitelli","startDate":"2005-10","conditions":"Diabetic Nephropathy","enrollment":850},{"nctId":"NCT00000620","phase":"PHASE3","title":"Action to Control Cardiovascular Risk in Diabetes (ACCORD)","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"1999-09","conditions":"Atherosclerosis, Cardiovascular Diseases, Hypercholesterolemia","enrollment":10251},{"nctId":"NCT02817503","phase":"PHASE4","title":"Feasibility Study of the Intensive Systolic Blood Pressure Control","status":"UNKNOWN","sponsor":"Second Affiliated Hospital of Nanchang University","startDate":"2015-12","conditions":"Hypertension, Hyperhomocysteinemia","enrollment":100},{"nctId":"NCT01198496","phase":"PHASE4","title":"Recurrent Stroke Prevention Clinical Outcome Study","status":"UNKNOWN","sponsor":"Biomedis International Ltd.","startDate":"2010-10","conditions":"Hypertension, Stroke, Blood Pressure","enrollment":5000},{"nctId":"NCT01180413","phase":"PHASE4","title":"Intensive Vasodilator Therapy in Patients With Essential Hypertension","status":"COMPLETED","sponsor":"Aarhus University Hospital","startDate":"2010-12","conditions":"Essential Hypertension, High Blood Pressure","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8062,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Amlodipine+intensive antihypertensive therapy","genericName":"Amlodipine+intensive antihypertensive therapy","companyName":"Beijing Tiantan Hospital","companyId":"beijing-tiantan-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amlodipine blocks L-type calcium channels in vascular smooth muscle to reduce blood pressure, often combined with other antihypertensive agents for enhanced efficacy. Used for Hypertension (as part of intensive antihypertensive regimen), Angina pectoris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}